Small Cell Variant of Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma of the Dura Mimicking Tentorial Meningioma

World Neurosurgery
Yudai HiranoNobuhito Saito

Abstract

Primary central nervous system (CNS) anaplastic large cell lymphoma (ALCL) is an uncommon type of brain tumor, usually treated with a regimen that includes high-dose methotrexate (MTX). Only a few cases of primary CNS anaplastic lymphoma kinase (ALK)-positive ALCL have been reported so far, with no reported cases of a small cell variant. A 26-year-old man presenting with headache and visual field impairment was found to have a supratentorial mass mimicking meningioma. Craniotomy was performed for tumor resection, and postoperative histologic examination revealed atypical cells that were nonenlarged lymphocytes with irregularly shaped and enlarged nuclei; these cells were cluster of differentiation 30 and ALK-positive, leading to the diagnosis of a small cell variant of ALK-positive ALCL. In this case, the tumor exhibited an aggressive behavior with MTX resistance with metastases in the pelvis but responded well to cytarabine and etoposide (CYVE). In general, CNS ALK-positive ALCL responds well to MTX, but small cell variants show aggressive behavior and may be resistant to MTX. For small cell variants of ALCL that are resistant to MTX therapy, as in this case, CYVE therapy may be an effective treatment.

References

Sep 1, 1993·The American Journal of Surgical Pathology·M C KinneyM E Kadin
Mar 27, 2003·The American Journal of Surgical Pathology·David H GeorgeCirilo Sotelo
May 24, 2007·Blood·Hesham M Amin, Raymond Lai
Nov 4, 2010·Archives of Pathology & Laboratory Medicine·Thomas A Summers, Joel T Moncur
Aug 4, 2011·Journal of Neuro-oncology·Nandita GhosalA S Hegde
Mar 22, 2014·Molecular and Clinical Oncology·Masashi NomuraSoichiro Shibui
Apr 20, 2014·Annals of Nuclear Medicine·Shigeru YamaguchiKiyohiro Houkin
Nov 18, 2017·Journal of Neuro-oncology·Domenico AlbanoFrancesco Bertagna
Feb 7, 2019·Insights Into Imaging·Daniel LyndonAnant S Krishnan

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