Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis

BioMed Research International
Mahboubeh RahmaniMina L Xu

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare non-Hodgkin B-cell lymphoma with a poor prognosis. While typically described as comprising large atypical cells restricted to the lumina of small blood vessels, it can show variability in cell size. To report the clinicopathologic features of the IVLBCL with small cell morphology and discuss the practical implications of our findings. We searched our archives for all IVLBCL diagnosed in our institution for the last 25 years (1992-2017). Slides were reviewed independently by two hematopathologists. We found a total of 11 cases of IVLBCL. Bone marrow, brain, lymph node, pericardium, small bowel, and fallopian tube and ovary were the organs in which the lymphoma was initially diagnosed. One of the cases initially diagnosed in the marrow showed intrasinusoidal involvement by a small cell lymphoma; the diagnosis was confirmed by random skin biopsies showing intravascular large cells with the same phenotype. Retrospective review of the liver on this case also showed the intrasinusoidal involvement by the disease consisting of small cells. In another case, IVLBCL that was initially diagnosed in a small bowel biopsy was retrospectively found in a breast biopsy, but with small cell ...Continue Reading

References

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Citations

Nov 12, 2019·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Jun 3, 2020·The Journal of International Medical Research·Aniello MaieseVittorio Fineschi

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Methods Mentioned

BETA
biopsies
biopsy
electrophoresis
PCR

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