PMID: 9165001May 1, 1997Paper

Small changes in essential amino acid concentrations alter diet selection in amino acid-deficient rats

The Journal of Nutrition
B J HrupkaQ R Rogers

Abstract

The rat's sensitivity to changes in the dietary limiting amino acid concentration (LAA) was examined on the basis of dietary selection. Rats were adapted to purified low protein basal (Basal) diets in which threonine (Thr) was the LAA (0.188-0.212% wt/wt of diet). In Experiment 1, rats made a clear selection for their adaptation diet over a diet containing 0.012% less threonine after 2-3 d of choice. Rats made no clear dietary selection when given a choice between their adaptation diet and a diet containing 0.012% more threonine. Experiment 2 was conducted to examine the rat's sensitivity to small decreases in the LAA concentration. Rats adapted to a 0.200% Thr-Basal diet clearly responded to decreases as small as 0.009% in the concentration of threonine and selected against the more deficient diet when given a choice between it and the 0.200% Thr-Basal adaptation diet. Because plasma and brain amino acid concentrations are important for detection of other amino acid deficiencies, these variables were measured to determine whether they were affected by such small changes in dietary amino acid concentration. In Experiments 3 and 4, rats were adapted to the 0.200% Thr-Basal diet and then fed 0.188, 0.200 or 0.212% Thr-Basal diets...Continue Reading

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Citations

Nov 12, 2003·Nutritional Neuroscience·J Ernie BlevinsDorothy W Gietzen
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector
Apr 23, 2008·Current Protocols in Neuroscience·Robin B Kanarek
Mar 3, 2007·Annual Review of Nutrition·Dorothy W GietzenTracy G Anthony
Jan 21, 2006·Journal of Animal Science·F X RothT Ettle
Dec 2, 2005·Annual Review of Psychology·Wolfram Schultz
Jun 26, 2015·Physiological Reviews·Wolfram Schultz
Jul 3, 1998·The Journal of Nutrition·L L BellingerD W Gietzen
Jul 11, 1998·Journal of Neurophysiology·W Schultz
Feb 20, 1999·The Journal of Nutrition·B J HrupkaQ R Rogers
Jan 7, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Patrick C EvenDaniel Tomé
Jul 31, 2004·The Journal of Nutrition·Quinton R RogersJames G Morris
Mar 23, 2007·Experimental Gerontology·Ghislaine Nzang NguemaJosette Alliot
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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