PMID: 9164993May 1, 1997Paper

Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats

The Journal of Nutrition
J A JumpsenM T Clandinin

Abstract

It has been suggested that the fat composition of infant formula should provide arachidonic acid [20:4(n-6)] and docosahexaenoic acid [22:6(n-3)] or increased alpha-linolenic acid [18:3(n-3)] to optimize the (n-3) and (n-6) fatty acid content of brain during infant development. This experiment examined the effects of feeding increased levels of 18:3(n-3), 20:4(n-6) and 22:6(n-3) on brain development in neonatal rats. Diets varying in (n-6) and (n-3) fatty acid content with or without 20:4(n-6) or 22:6(n-3), at levels proposed for infant formula, were fed to nursing dams from parturition and subsequently to weaned pups until 6 wk of age. Neuronal and glial cells were isolated from the frontal region, cerebellum and hippocampus of the brain. Fatty acid analyses of ethanolamine- and choline-phosphoglycerides indicated that small changes in the dietary (n-6)/(n-3) ratio significantly altered neuronal and glial membrane fatty acid composition. Brain regions and cell types varied in amount and rate of 20:4(n-6) and 22:6(n-3) accretion. Fatty acid composition of individual phosphoglycerides was distinct and exhibited changes with age. Inclusion of both 20:4(n-6) and 22:6(n-3) in the diet resulted in alteration of brain fatty acid comp...Continue Reading

References

Dec 15, 1977·Experientia·G D Das
Jan 1, 1991·World Review of Nutrition and Dietetics·H Sprecher
Apr 2, 1990·Biochimica Et Biophysica Acta·J M BourreH Lafont
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·M T ClandininJ E van Aerde
Apr 26, 1989·Biochimica Et Biophysica Acta·J L Zevenbergen, U M Houtsmuller
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F VitielloG Gombos
Jan 1, 1987·Annals of Nutrition & Metabolism·T A Sanders, S K Rana
Jun 15, 1988·Biochimica Et Biophysica Acta·J M BourreH Lafont
Sep 2, 1988·Biochimica Et Biophysica Acta·K M Hargreaves, M T Clandinin
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M NeuringerS Luck
Nov 1, 1987·Journal of Pediatric Gastroenterology and Nutrition·B KoletzkoG Harzer
Feb 1, 1974·Pediatric Research·M MartinezA Ballabriga
Sep 1, 1981·Early Human Development·M T ClandininG W Chance
Jun 1, 1980·Early Human Development·M T ClandininG W Chance
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·P J MorganeJ R Galler

❮ Previous
Next ❯

Citations

Mar 18, 1999·Nutrition Reviews·I P Wauben, P E Wainwright
Jul 29, 2005·Critical Reviews in Food Science and Nutrition·M Fleith, M T Clandinin
Feb 2, 2010·Journal of Pediatric Gastroenterology and Nutrition·Eek J ParkMichael T Clandinin
Jul 28, 2017·Journal of Autism and Developmental Disorders·Kelly W SheppardSarah A Keim
Dec 7, 2007·The European Journal of Neuroscience·José Luis AlbasanzMairena Martín
Dec 29, 2015·Current Opinion in Lipidology·Shoug M AlashmaliRichard P Bazinet
May 10, 2018·Frontiers in Cellular Neuroscience·Jose L HerreraFrancisco G Wandosell
Jan 24, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kit-Yi YamAniko Korosi
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K A YoudimJ A Joseph
Jan 5, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Noran M Abu-Ouf, Mohammed M Jan
Dec 14, 2002·Annals of the New York Academy of Sciences·Eszter FarkasPaul G M Luiten
Oct 31, 2006·Journal of Psychiatric Research·Shih-Yi HuangKuan-Pin Su
Jun 16, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Marshall D McCueBerry Pinshow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.