PMID: 8468509Mar 1, 1993Paper

Small cylindrical ultrasound sources for induction of hyperthermia via body cavities or interstitial implants

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
K Hynynen, K L Davis

Abstract

In this study, small (outside diameter 1 mm) cylindrical ultrasound sources were investigated for induction of hyperthermia in tumours. These ultrasound transducers could be placed in small-diameter body cavities, or they could be used interstitially in brachytherapy catheters. The ultrasound field measurements showed that the field is fairly uniform as a function of the length of the applicator except at the ends where sharp peaks were located. However, there were significant field variations as a function of rotation angle around the transducers. The degree of these non-uniformities varied from transducer to transducer, and also as a function of frequency. The temperature measurements in vitro perfused kidneys showed that therapeutic temperature elevations could be induced in perfused tissues. The radial extent of the therapeutic zone could be increased by circulating water around the applicators, thus avoiding high temperatures on the applicator surface. It was also shown that some control over the temperature distribution along the length of the applicator could be achieved by using a two-element applicator. An array of four applicators implanted in a square pattern with the spacing of 25 mm between the catheters, was able ...Continue Reading

References

Jul 1, 1992·Medical Physics·K Hynynen
Apr 1, 1989·IEEE Transactions on Bio-medical Engineering·C J Diederich, K Hynynen
Nov 1, 1987·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J Overgaard, M Overgaard

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Citations

Jul 1, 1999·Ultrasound in Medicine & Biology·D L Deardorff, C J Diederich
Aug 26, 1999·Ultrasound in Medicine & Biology·C J Diederich, K Hynynen
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·R S KaateeA G Visser
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·W L LinM J Shieh
Nov 8, 2011·Theoretical Biology & Medical Modelling·Mark R BrintonYan-Ting E Shiu
Feb 18, 2005·Nihon rinsho. Japanese journal of clinical medicine·Toyoaki Uchida
May 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C J DiederichT L Phillips
Mar 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C J Diederich
Jun 21, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C LafonJ Y Chapelon
Feb 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·B J Jarosz, D Kaytar
Sep 1, 1995·IEEE Transactions on Bio-medical Engineering·J E ZimmerF Marcus
Feb 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Y Y BotrosJ L Volakis
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·D L Deardorff, C J Diederich
Feb 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·C J DiederichP R Stauffer
Feb 1, 1997·IEEE Transactions on Bio-medical Engineering·K HynynenM Aguirre
Jul 9, 1999·IEEE Transactions on Bio-medical Engineering·R J LeeK Hynynen
Nov 1, 1996·IEEE Transactions on Bio-medical Engineering·B J Jarosz
Nov 4, 2000·IEEE Transactions on Bio-medical Engineering·D L Deardorff, C J Diederich
Sep 29, 2004·Prostate Cancer and Prostatic Diseases·M Colombel, A Gelet
Dec 8, 2019·Scientific Reports·Kang ChenTakeshi Morita

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