Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis

Journal of Clinical Lipidology
Hala HusseinAnatol Kontush

Abstract

Familial hypercholesterolemia (FH) features elevated oxidative stress and accelerated atherosclerosis driven by elevated levels of atherogenic lipoproteins relative to subnormal levels of atheroprotective high-density lipoprotein (HDL). Small, dense HDL3 potently protects low-density lipoprotein (LDL) against proinflammatory oxidative damage. To determine whether antioxidative and/or anti-inflammatory activities of HDL are defective in FH and whether such defects are corrected by LDL apheresis. Antioxidative and antiinflammatory activities of HDL were evaluated as protection of reference LDL from oxidative stress and capacity to prevent accumulation of proinflammatory oxidised lipids, respectively. Lipid surface rigidity of HDL was assessed using a fluorescent probe. HDL components were measured by analytical approaches. Systemic oxidative stress was characterized as plasma 8-isoprostanes. Pre-LDL-apheresis, FH patients (n = 10) exhibited elevated systemic oxidative stress (3.3-fold, P < 0.001) vs. sex- and age-matched normolipidemic controls (n = 10). Both antioxidative and antiinflammatory activity of HDL3 were impaired (up to -91%, P < 0.01) in FH. Sphingomyelin and saturated fatty acid contents were elevated in FH HDL3, res...Continue Reading

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Citations

Nov 20, 2016·European Journal of Clinical Investigation·Miguel A FriasJonas W Brinck
Jan 13, 2018·Journal of Cellular Physiology·Hamid MollazadehAmirhossein Sahebkar
Jun 1, 2018·Current Medicinal Chemistry·Angela PirilloGiuseppe Danilo Norata
Apr 14, 2016·Current Opinion in Lipidology·Maryam Darabi, Anatol Kontush
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Jun 13, 2020·Seminars in Arthritis and Rheumatism·Shiva GanjaliAmirhossein Sahebkar
Mar 30, 2021·Biochemistry and Biophysics Reports·Sandra Y Valencia CPatricia Landázuri
Apr 30, 2021·Current Atherosclerosis Reports·Joan Carles Escolà-GilFrancisco Blanco-Vaca
Aug 7, 2021·Biomedicines·Juan Pedro-BotetDavid Benaiges

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