Small dense LDL cholesterol in human subjects with different chronic inflammatory diseases

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
D M SchulteM Laudes

Abstract

Chronic inflammatory diseases (CID) are associated with a profound increase in cardiovascular (CV) risk resulting in reduced life expectancy. However, LDL-cholesterol is reported to be low in CID patients which is referred to as the "LDL paradoxon". The aim of the present study was to investigate whether LDL-particles in CID exhibit an increased content of the highly atherogenic small-dense LDL subfraction (sdLDL). In this prospective, single center, observational study we enrolled 141 patients with CID (RA n = 59, inflammatory bowel disease (IBD) n = 35, ankylosing spondylitis (SpA) n = 25, Psoriasis n = 22) in 2011 through 2013 to evaluate sdLDL levels before as well as 6 and 26 weeks after initiation of different anti-cytokine therapies (anti-TNFα, anti-IL-6R antibodies). sdLDL levels were compared to 141 healthy individuals in a case control design. Compared to healthy controls, all CID patients displayed a significantly higher sdLDL content within the LDL cholesterol fraction: RA 35.0 ± 9.2% (p < 0.001), SpA 42.5 ± 10.5% (p < 0.001), IBD 37.5 ± 7.1% (p < 0.001), Psoriasis 33.6 ± 4.6% (p < 0.01). Furthermore, the sdLDL/LDL ratio was significantly higher in male compared to female RA subjects (p < 0.05). Neither anti-TNFα no...Continue Reading

Citations

May 31, 2019·Current Opinion in Lipidology·Rachel H MackeyLarry W Moreland
Jan 30, 2020·Diagnostics·Michael Y HeneinFederico Vancheri
Aug 15, 2020·Scientific Reports·Hanieh Marvi KhorasaniLourdes Peña-Castillo
Jul 9, 2020·International Journal of Molecular Sciences·Yi-Hsiung LinChung-Hwan Chen
Jul 25, 2019·Current Vascular Pharmacology·Charalampos PapagorasAlexandros A Drosos
Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisBasant K Puri
Aug 12, 2021·Therapeutic Advances in Gastroenterology·Jasmijn A M SleutjesAnnemarie C de Vries
Aug 29, 2021·Alimentary Pharmacology & Therapeutics·Jasmijn A M SleutjesAnnemarie C de Vries

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