Small dense low-density lipoprotein: Analytical review.

Clinica Chimica Acta; International Journal of Clinical Chemistry
Christina Kanonidou

Abstract

The causal relationship between low-density lipoprotein (LDL) and atherosclerotic cardiovascular disease (CVD) has been firmly substantiated. LDL consists of a heterogeneous group of particles with different physicochemical and metabolic properties. Among them, small dense LDL (sdLDL) particles are considered an emerging CVD risk factor and a promising CVD risk biomarker. This paper reviews published analytical and calculation-based methods for sdLDL determination in plasma, present their principles, strengths, and weaknesses, and examine the challenges arising from method comparison. A literature survey was conducted using the PubMed database. Subject headings and keywords facilitated the search strategy. Titles and abstracts were initially assessed, and the full-text article of the pre-selected ones was reviewed. A range of methods is currently available for the analysis of LDL subfractions and the measurement of sdLDL particle size, number, and cholesterol concentration. Ultracentrifugation (UC), vertical auto profile, gradient gel electrophoresis (GGE), nuclear magnetic resonance (NMR) spectroscopy, high-performance liquid chromatography, ion mobility analysis, and a homogeneous assay are the most prevalent. To date, there ...Continue Reading

References

Jul 1, 1994·Clinical Genetics·M A Austin
Jul 10, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·M OkazakiS Hosaki
Jul 27, 1999·British Journal of Clinical Pharmacology·I RajmanJ M Ritter
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Nov 18, 2006·Clinics in Laboratory Medicine·Krishnaji R Kulkarni
Nov 18, 2006·Clinics in Laboratory Medicine·Elias J JeyarajahJames D Otvos
Jun 3, 2008·Clinical Chemistry·Michael P CaulfieldRonald M Krauss
Dec 2, 2008·Clinical Chemistry·James D OtvosJoseph P McConnell
Jun 1, 2006·Current Opinion in Colloid & Interface Science·J Bruce GermanAngela M Zivkovic
Nov 6, 2010·Clinical Chemistry·Yasuki ItoTsutomu Hirano
Jun 21, 2011·American Journal of Clinical Pathology·Pornpen SrisawasdiMartin H Kroll
Oct 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Celia BañulsAntonio Hernández-Mijares
Sep 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Satoshi Hirayama, Takashi Miida
Jul 11, 2013·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·John J SninskyHarold Robert Superko
Aug 1, 2013·Annals of Clinical Biochemistry·Toshihiro SakuraiHitoshi Chiba
Aug 1, 2014·Clinical Biochemistry·Steven P MatyusTimothy J Fischer
Jan 9, 2015·Journal of Lipid Research·Roger MallolXavier Correig
Mar 3, 2015·Diabetologia·Bruno Vergès
Apr 22, 2015·FEBS Open Bio·Chaoye GanYong Chen
Apr 26, 2015·Journal of Lipid Research·William H MunroeVerne N Schumaker
May 24, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Roberto FerrariAlberico L Catapano
Jun 3, 2017·Oxidative Medicine and Cellular Longevity·Ekaterina A IvanovaAlexander N Orekhov
Jan 18, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·I Ramasamy

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