Small Dense Low Density Lipoprotein Cholesterol, Paraoxonase 1 and Lipid Profile in Postmenopausal Women: Quality or Quantity?

Archives of Medical Research
Mukund Ramchandra Mogarekar, Shyam K Kulkarni

Abstract

Atherosclerosis, the root cause of cardiovascular disease (CVD), has a number of risk factors-some modifiable and some not. CVD increases in women particularly during the postmenopausal period. Small dense low-density lipoprotein (sdLDL), a subclass of LDL, is an important determinant of atherosclerosis in postmenopausal women. Paraoxonase1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme that prevents oxidative modifications in LDL and HDL. With this background, we studied the sdLDL-C, PON1 and lipid profile in postmenopausal women to compare between quality and quantity of LDL. We studied 80 pre- and postmenopausal women (40/group). The following parameters were studied: lipid profile, sdLDL-C and PON1 levels. With proper statistical tools the correlation between these parameters was studied. Postmenopausal women, in comparison with premenopausal women, have significantly increased levels of serum triglycerides and sdLDL-C and very-low-density lipoprotein cholesterol (VLDL-C) and significantly decreased levels of HDL-C and PON1. PON1 activity was negatively correlated with age, TC, TG, LDL-C and sdLDL-C (r = -0.574, -0.119, -0.226, -0.473 and -0.455, respectively) and positively correlated with HDL-C (r = 0.368), ...Continue Reading

References

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Citations

Apr 21, 2017·Current Opinion in Cardiology·Philipp A GerberManfredi Rizzo
Aug 5, 2017·Climacteric : the Journal of the International Menopause Society·Y SunA O Mueck
May 30, 2019·Journal of Clinical Biochemistry and Nutrition·Alessandro TrentiniCarlo Cervellati
Jun 20, 2020·Hormones : International Journal of Endocrinology and Metabolism·Hongwei LiYuling Zhang
Sep 17, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hyejin KimJeongseon Kim

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