Small-diameter nerve fiber neuropathy in systemic lupus erythematosus

Archives of Neurology
Lasse G GøranssonRoald Omdal

Abstract

Systemic lupus erythematosus (SLE) is an inflammatory, autoimmune, multiorgan disease often involving the central and peripheral nervous systems. To determine whether there is a selective small-diameter nerve fiber neuropathy in patients with SLE. Cross-sectional study. Stavanger University Hospital, Stavanger, Norway. Patients Sixty patients with SLE, aged 43.2 +/- 13.5 years (mean +/- SD). Skin biopsies, nerve conduction studies, and clinical neurologic examinations. Density of intraepidermal small-diameter nerve fibers in skin biopsy specimens and large-diameter nerve fiber function as determined by nerve conduction studies and clinical examinations. The mean density of intraepidermal small-diameter nerve fibers in patients with SLE was 7.5 +/- 3.8/mm. Eight patients (13%) had densities below reference values, consistent with small-diameter nerve fiber neuropathy, and results of nerve conduction studies were normal in 6 of them. Eleven patients (18%) had abnormal results of nerve conduction studies, reflecting large-diameter nerve fiber neuropathy, and 4 patients (7%) were classified by an experienced neurologist as having polyneuropathy after the clinical examination. An abnormal reduction in intraepidermal small-diameter n...Continue Reading

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