Abstract
Systemic lupus erythematosus (SLE) is an inflammatory, autoimmune, multiorgan disease often involving the central and peripheral nervous systems. To determine whether there is a selective small-diameter nerve fiber neuropathy in patients with SLE. Cross-sectional study. Stavanger University Hospital, Stavanger, Norway. Patients Sixty patients with SLE, aged 43.2 +/- 13.5 years (mean +/- SD). Skin biopsies, nerve conduction studies, and clinical neurologic examinations. Density of intraepidermal small-diameter nerve fibers in skin biopsy specimens and large-diameter nerve fiber function as determined by nerve conduction studies and clinical examinations. The mean density of intraepidermal small-diameter nerve fibers in patients with SLE was 7.5 +/- 3.8/mm. Eight patients (13%) had densities below reference values, consistent with small-diameter nerve fiber neuropathy, and results of nerve conduction studies were normal in 6 of them. Eleven patients (18%) had abnormal results of nerve conduction studies, reflecting large-diameter nerve fiber neuropathy, and 4 patients (7%) were classified by an experienced neurologist as having polyneuropathy after the clinical examination. An abnormal reduction in intraepidermal small-diameter n...Continue Reading
Citations
Jun 6, 2008·Brain : a Journal of Neurology·Grazia DevigiliGiuseppe Lauria
Feb 11, 2014·Disease-a-month : DM·Gary W Jay, Robert L Barkin
Jun 22, 2007·Lancet Neurology·Claudia Sommer, Giuseppe Lauria
Dec 23, 2011·Muscle & Nerve·Sara Khan, Lan Zhou
Jul 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G LauriaUNKNOWN Peripheral Nerve Society
Apr 24, 2014·Arthritis & Rheumatology·A OomatiaJ Birnbaum
Sep 26, 2014·Lupus·R JasminKj Goh
May 16, 2014·Journal of Clinical Neurology·Kristin SamuelssonRayomand Press
Dec 4, 2009·Current Diabetes Reports·Roy Freeman
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·UNKNOWN Joint Task Force of the EFNS and the PNS
Nov 3, 2010·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaIngemar S J Merkies
Dec 20, 2007·Journal of Neuropathology and Experimental Neurology·Gigi J EbenezerMichael Polydefkis
Feb 3, 2011·Current Pain and Headache Reports·Alexandra Hovaguimian, Christopher H Gibbons
Sep 4, 2012·Current Opinion in Neurology·Giuseppe LauriaCatharina G Faber
Aug 8, 2019·Arthritis & Rheumatology·John G HanlyVernon Farewell
Jul 1, 2017·Current Opinion in Neurology·Daniele Cazzato, Giuseppe Lauria
Jun 19, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Marco MulaFrancesco Monaco
May 29, 2018·Arquivos de neuro-psiquiatria·Francisco de Assis Aquino GondimPedro Schestatsky
Aug 27, 2019·Therapeutic Advances in Neurological Disorders·Jo M WilmshurstMonique M Ryan
Feb 7, 2018·Therapeutic Advances in Neurological Disorders·Xiaolei LiuAnne Louise Oaklander
Feb 11, 2015·Expert Review of Neurotherapeutics·Ming-Chang ChiangSung-Tsang Hsieh
Nov 14, 2019·Brain Sciences·Eric A Moulton, David Borsook
Jun 7, 2020·Advances in Rheumatology·Aslan TekatasOmer Nuri Pamuk
Dec 19, 2020·Journal of Neuromuscular Diseases·Lisette R M RaasingJan C Grutters
Mar 31, 2021·Rheumatic Diseases Clinics of North America·David S PisetskyJennifer L Rogers
Mar 27, 2021·Neurology·Margot GeertsIngemar S J Merkies