Small-diameter vascular graft using co-electrospun composite PCL/PU nanofibers

Biomedical Materials
Nafiseh JiroftiGholam Hossein Kazemzadeh

Abstract

Small-diameter vascular scaffolds have been developed by a co-electrospinning method using polyethylene terephthalate (PCL) and elastic polytetrafluoroethylene (PU) as biopolymers with long degradation time. Although they possess favorable properties, individually these two polymers do not meet the requirements for the production of synthetic vascular scaffolds. The co-electrospinning method was adopted to develop and mechanically improve the composite PCL/PU vascular scaffolds. The morphological, mechanical and biological properties of these vascular scaffolds were evaluated through scanning electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, compliance, tensile testing and MTT assay. The in vivo study of the vascular scaffolds was performed by implanting them on rat and sheep models. The compliance of the composite vascular scaffolds improved by up to 43% through an increased percentage of PU from 10%-90%. The obtained UTS of the scaffolds at 10%, 25%, 50%, 75% and 90% of PU were 4.7 ± 0.34, 3.4 ± 0.6, 4.8 ± 0.62, 2.2 ± 0.34 and 4.4 ± 1.9 MPa, respectively. The results of MTT assays indicated that the cell growth on the scaffolds was augmented when compared to the control, from day...Continue Reading

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Citations

Mar 10, 2020·Journal of Biomaterials Applications·Saeed AkbariAbdolreza Samimi
Apr 8, 2020·Biomedical Materials·Nafiseh JiroftiGholam Hossein Kazemzadeh
Jul 2, 2020·International Journal of Nanomedicine·Saeed Mohammadi NasrThomas J Webster
Oct 3, 2021·Journal of Biomedical Materials Research. Part a·Pengchong DuLiang Zhao

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