Small-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response study.

Anesthesia and Analgesia
Stephan StrebelChristoph H Kindler

Abstract

We examined the dose-response relationship of intrathecal clonidine at small doses (<or=150 microg) with respect to prolonging bupivacaine spinal anesthesia. We aimed for establishing doses of intrathecal clonidine that would produce clinically relevant prolongation of spinal anesthesia and pain relief without significant side effects. Eighty orthopedic patients were randomly assigned to intrathecally receive isobaric 0.5% bupivacaine, 18 mg, plus saline (Group 1), clonidine 37.5 microg (Group 2), clonidine 75 microg (Group 3), and clonidine 150 microg (Group 4). Duration of the sensory block (regression below level L1) was increased in patients receiving intrathecal clonidine: 288 +/- 62 min (Group 1, control), 311 +/- 101 min in Group 2 (+8%), 325 +/- 69 min in Group 3 (+13%), and 337 +/- 78 min in Group 4 (+17%) (estimated parameter for dose 0.23 [95% confidence interval -0.05-0.50]). Duration of pain relief from intrathecal clonidine administration until the first request for supplemental analgesia was significantly prolonged: 295 +/- 80 min (Group 1, control), 343 +/- 75 min in Group 2 (+16%), 381 +/- 117 min in Group 3 (+29%), and 445 +/- 136 min in Group 4 (+51%) (estimated parameter for dose 1.02 [95% confidence interva...Continue Reading

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Citations

Feb 15, 2011·Pakistan Journal of Biological Sciences : PJBS·H TalebiM Kalantarian
Jun 10, 2011·Saudi Journal of Anaesthesia·Nikhil KothariAjay K Chaudhary
Oct 10, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Velayudha Sidda ReddyVenkatsiva Jangam
Jul 10, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·A F Ouro-Bang'na MamanM Chobli
Aug 21, 2012·Anesthesiology Clinics·Lawrence T LaiAudrée A Bendo
Sep 7, 2011·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Donna JarzynaRosemary C Polomano
Sep 22, 2007·Anesthesiology Clinics·Jose Ortiz-Cardona, Audrée A Bendo
Jan 25, 2006·Acta Anaesthesiologica Scandinavica·G E KanaziA S Baraka
Oct 15, 2013·CNS Neuroscience & Therapeutics·Xiao-Yin NiuQuan Li
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Dec 25, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Neeru SahniPushpa Jagannath
Jun 9, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Usha ShuklaDheeraj Srivastava
Jun 29, 2016·Biological & Pharmaceutical Bulletin·Xiaofei QiYong Li
Jan 23, 2013·Acta Cirúrgica Brasileira·Angélica de Fátima de Assunção BragaStella Marys Meirelles Campos Titotto
Jun 10, 2014·Korean journal of anesthesiology·Sang Hi ParkKyoung Hoon Yim
Nov 15, 2008·Current Opinion in Anaesthesiology·Brian D O'Donnell, Gabriella Iohom
Sep 15, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Aline Stamford S G Gatis-CarrazzoniTeresinha Gonçalves da Silva

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