Small-dose propofol by continuous infusion does not prevent postoperative vomiting in females undergoing outpatient laparoscopy

Anesthesia and Analgesia
P E ScuderiR L James

Abstract

This study was designed to test the hypothesis that there is a direct prophylactic antiemetic effect of small-dose propofol given by continuous infusion. Sixty female patients undergoing outpatient laparoscopy under general anesthesia were randomized to receive, in a double-blind fashion, either a bolus of 0.1 mg/kg followed by a constant infusion of 1 mg.kg-1.h-1 of propofol or an equivalent volume of 10% Intralipid (placebo) beginning 30 min before induction of anesthesia and continuing until discharge from Stage I postanesthesia care unit (PACU). Anesthesia was induced and maintained in a standard fashion in all patients. The number of emetic episodes before and after discharge from PACU, nausea scores (11-point numerical scale), and time to discharge were evaluated. No significant differences between Intralipid and propofol were found for any of the outcome variables tested. While small-dose propofol is an effective adjuvant in reducing chemotherapy-induced emesis, we were unable to demonstrate any beneficial effect of propofol in reducing postoperative nausea and vomiting when used as the sole prophylactic medication in this patient population. Propofol may have a synergistic effect when administered with other antiemetics...Continue Reading

References

Jan 1, 1975·Canadian Anaesthetists' Society Journal·D J Steward
Feb 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C S ScherS M Barst
Apr 1, 1992·Anesthesia and Analgesia·A BorgeatK Rifat
Dec 1, 1989·Anesthesia and Analgesia·B MelnickR Patel
Nov 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K KorttilaM F Roizen
Sep 1, 1988·Anesthesiology·B M Melnick
Jan 1, 1983·Annals of Internal Medicine·R Albibi, R W McCallum
Jan 1, 1984·Anesthesiology·S E CohenJ Wyner
Nov 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A BorgeatP M Suter
Mar 1, 1994·Anesthesiology·A BorgeatP M Suter

❮ Previous
Next ❯

Citations

Aug 24, 1999·Lasers in Surgery and Medicine·R L Trytko, W P Werschler
Jan 5, 2002·Obstetrics and Gynecology·Yoshitaka Fujii, Mitsuko Numazaki
Mar 14, 2001·Anesthesiology Clinics of North America·I Smith
May 1, 1998·Acta Anaesthesiologica Scandinavica·B HammasM Wattwil
Dec 23, 2010·Anesthesia Progress·Daniel E Becker
Feb 1, 2011·Current Therapeutic Research, Clinical and Experimental·Mustafa ArslanHüseyin Yilmaz
May 4, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·G Audibert, V Vial
Jun 19, 2003·Anesthesiology Clinics of North America·Nina Deutsch, Christopher L Wu
Oct 24, 2003·International Anesthesiology Clinics·Christian C Apfel, Norbert Roewer
Oct 3, 2006·Current Opinion in Anaesthesiology·R Y Fragneto
Oct 4, 2006·Current Opinion in Anaesthesiology·R L Harter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.