Small, Enigmatic Plasmids of the Nosocomial Pathogen, Acinetobacter baumannii: Good, Bad, Who Knows?

Frontiers in Microbiology
Soo Sum Lean, Chew Chieng Yeo

Abstract

Acinetobacter baumannii is a Gram-negative nosocomial pathogen that has become a serious healthcare concern within a span of two decades due to its ability to rapidly acquire resistance to all classes of antimicrobial compounds. One of the key features of the A. baumannii genome is an open pan genome with a plethora of plasmids, transposons, integrons, and genomic islands, all of which play important roles in the evolution and success of this clinical pathogen, particularly in the acquisition of multidrug resistance determinants. An interesting genetic feature seen in majority of A. baumannii genomes analyzed is the presence of small plasmids that usually ranged from 2 to 10 kb in size, some of which harbor antibiotic resistance genes and homologs of plasmid mobilization genes. These plasmids are often overlooked when compared to their larger, conjugative counterparts that harbor multiple antibiotic resistance genes and transposable elements. In this mini-review, we will examine our current knowledge of these small A. baumannii plasmids and look into their genetic diversity and phylogenetic relationships. Some of these plasmids, such as the Rep-3 superfamily group and the pRAY-type, which has no recognizable replicase genes, ar...Continue Reading

References

Dec 1, 1995·Microbiology·G D Recchia, Ruth M Hall
Feb 21, 2004·FEMS Microbiology Reviews·M Victoria FranciaFernando de la Cruz
Jan 18, 2006·PLoS Genetics·Pierre-Edouard FournierJean-Michel Claverie
Jul 28, 2006·Cellular Signalling·Peer R E Mittl, Wulf Schneider-Brachert
Jun 3, 2009·Antimicrobial Agents and Chemotherapy·Marco Maria D'AndreaGian Maria Rossolini
Jul 28, 2010·Antimicrobial Agents and Chemotherapy·Alessia BertiniAlessandra Carattoli
Jun 30, 2011·FEMS Microbiology Reviews·Maria Pilar Garcillán-BarciaFernando de la Cruz
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Oct 4, 2011·The Journal of Antimicrobial Chemotherapy·Rémy A BonninPatrice Nordmann
Aug 14, 2012·The Journal of Antimicrobial Chemotherapy·Mohammad HamidianRuth M Hall
Feb 14, 2013·International Journal of Antimicrobial Agents·Chih-Chin LiuMing-Li Liou
Jul 3, 2013·Infection and Immunity·Daniel L ZimblerLuis A Actis
Dec 18, 2013·The Journal of Antimicrobial Chemotherapy·Mohammad Hamidian, Ruth M Hall
May 17, 2014·The Journal of Antimicrobial Chemotherapy·Stephan GöttigVolkhard A J Kempf
Jun 1, 2014·The Journal of Antimicrobial Chemotherapy·Noraida MosquedaGEIH-GEMARA (SEIMC) and REIPI
Oct 19, 2014·BMC Research Notes·Bianca GiffordSteve Petrovski
Apr 8, 2015·Journal of Bacteriology·Larry A GallagherColin Manoil
Jun 25, 2015·Microbiology Spectrum·Sabine Brantl
Jun 25, 2015·Microbiology Spectrum·Igor KoniecznyKatarzyna Wegrzyn
Jun 25, 2015·Microbiology Spectrum·Caroline Midonet, Francois-Xavier Barre
Sep 30, 2015·The Journal of Antimicrobial Chemotherapy·Mohammad HamidianRuth M Hall
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura

Citations

Aug 3, 2018·Clinical Microbiology Reviews·Sally R PartridgeSlade O Jensen
Aug 31, 2019·Future Microbiology·Rayane RafeiMonzer Hamze
Jul 7, 2020·Frontiers in Microbiology·Abraham D Salgado-CamargoMiguel A Cevallos
Jul 14, 2020·World Journal of Microbiology & Biotechnology·Marco A BrovedanGuillermo D Repizo
Jan 17, 2020·Annals of Clinical Microbiology and Antimicrobials·Nabil KarahIrfan Ahmad
Jan 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Gisela Di VenanzioMario F Feldman
Aug 15, 2019·Emerging Microbes & Infections·Ethel-Michele de VilliersHarald Zur Hausen
Feb 23, 2019·Antimicrobial Resistance and Infection Control·Pierrette Landrie Simo TchuinteJean-Marc Collard
May 15, 2020·Clinical Microbiology Reviews·David M P De OliveiraMark J Walker
Dec 12, 2020·Frontiers in Microbiology·S Z MindlinM A Petrova
Oct 13, 2020·International Journal of Antimicrobial Agents·Carlos Henrique CamargoMonique Ribeiro Tiba-Casas

Datasets Mentioned

BETA
AB5075

Methods Mentioned

BETA
electrophoresis

Related Concepts

Related Feeds

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.