Small GTPase-regulated phospholipase D in granulocytes

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
M G Houle, S Bourgoin

Abstract

This review examines the functional role of phospholipase D in the neutrophil. Phospholipase D is emerging as an important component in the signal transduction pathways leading to granulocyte activation. Through the second messenger it produces, phosphatidic acid, phospholipase D plays an active role in the regulation of granulocyte NADPH oxidase activation and granular secretion. Many factors from both the cytosol and the membrane are necessary for maximal phospholipase D activation. This paper will focus on the regulation of phospholipase D by low molecular weight GTP-binding proteins, tyrosine kinases, and protein kinase C.

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Citations

Aug 28, 1998·Cellular Signalling·J Gomez-Cambronero, P Keire
Mar 16, 2001·The Journal of Eukaryotic Microbiology·J J BlumJ Gomez-Cambronero
Nov 27, 2015·Journal of Immunology Research·Jouda GamaraSylvain G Bourgoin
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May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline GilbertPaul H Naccache
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I LavelinM Pines

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