Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons

Neuroscience Letters
Yukio IshikawaManabu Negishi

Abstract

Rho family small GTPases are key regulators for neuronal morphogenesis including dendritogenesis. We recently have shown that Rnd1, a member of the Rho family, is highly expressed in brain during the synaptogenic stage and is involved in dendritic spine formation. However, the mechanism by which Rnd1 regulates dendritic development including spine morphogenesis remains unknown. Here we report that Rnd1, a member of the Rho family, plays a critical role in neuronal activity-dependent dendritic development in hippocampal neurons. Overexpression of Rnd1 promoted dendritic growth and branching in cultured hippocampal neurons. On the other hand, suppression of endogenous Rnd1 expression by RNA interference significantly inhibited neuronal activity-dependent dendritic development and this inhibitory effect was canceled by inhibition of RhoA effector ROCK. In addition, knockdown of Rnd1 also abolished dendritic development promoted by treatment with brain-derived neurotrophic factor in hippocampal neurons. Our findings demonstrate that Rnd1 is involved in signaling pathways of neuronal activity-dependent dendritic development.

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Citations

Jul 20, 2011·The Journal of Biological Chemistry·Yohei WakitaManabu Negishi
Mar 4, 2005·Molecular Biology of the Cell·Ryan T Terry-LorenzoMichael D Ehlers
Feb 24, 2012·Molecular Biology of the Cell·Izumi OinumaManabu Negishi
May 18, 2012·Molecular Biology of the Cell·Nariaki IwasawaIzumi Oinuma
Jul 20, 2007·Journal of Cell Science·Carlene D MooreAnne Theibert
May 16, 2013·PloS One·Florian GiesertWolfgang Wurst
Jan 1, 2014·BMC Medical Genomics·Meaghan J JonesMichael S Kobor
Apr 3, 2014·Experimental Cell Research·Luiz Eduardo Rizzo de SouzaSilvio Marques Zanata
Jul 11, 2009·Neuroscience·B Ballester-LurbeJ Terrado
May 16, 2009·EMBO Reports·Yasuhiro SaitoManabu Negishi
Jan 22, 2009·Journal of Neuroscience Research·Kazuya KuramotoHironori Katoh
Jul 11, 2008·Journal of Neuroscience Research·Shuhei UedaHironori Katoh
Apr 30, 2015·Journal of Biochemistry·Shingo TakeuchiManabu Negishi
Feb 26, 2014·Communicative & Integrative Biology·Annie Arguello, Benjamin Nr Cheyette
May 11, 2005·Progress in Neurobiology·Iryna M Ethell, Elena B Pasquale
May 21, 2005·Experimental Cell Research·Luisa BenussiGiuliano Binetti
Nov 11, 2008·The Journal of Biological Chemistry·Ying-Hua LiAndreas W Pu Schel
Nov 1, 2020·Scientific Reports·Li OuyangNancy Y Ip
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Boris LavanderosOscar Cerda
Oct 16, 2020·Small GTPases·Sara BasbousViolaine Moreau

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