Small GTPases and Their Role in Vascular Disease

International Journal of Molecular Sciences
Alison FlentjeThomas S Monahan

Abstract

Over eighty million people in the United States have cardiovascular disease that can affect the heart causing myocardial infarction; the carotid arteries causing stroke; and the lower extremities leading to amputation. The treatment for end-stage cardiovascular disease is surgical-either endovascular therapy with balloons and stents-or open reconstruction to reestablish blood flow. All interventions damage or destroy the protective inner lining of the blood vessel-the endothelium. An intact endothelium is essential to provide a protective; antithrombotic lining of a blood vessel. Currently; there are no agents used in the clinical setting that promote reendothelialization. This process requires migration of endothelial cells to the denuded vessel; proliferation of endothelial cells on the denuded vessel surface; and the reconstitution of the tight adherence junctions responsible for the formation of an impermeable surface. These processes are all regulated in part and are dependent on small GTPases. As important as the small GTPases are for reendothelialization, dysregulation of these molecules can result in various vascular pathologies including aneurysm formation, atherosclerosis, diabetes, angiogenesis, and hypertension. A b...Continue Reading

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Citations

Feb 13, 2020·International Journal of Molecular Sciences·Rita Moretti, Paola Caruso
Sep 10, 2020·International Journal of Molecular Sciences·Rita Moretti, Paola Caruso
Oct 8, 2020·International Journal of Molecular Sciences·Takaya Satoh
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Xuemei WuDengwen Li
Jan 30, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Zhuoyan LiSun Chen
Feb 6, 2021·International Journal of Molecular Sciences·Christian SchulzFriedrich Jung
Mar 7, 2021·International Journal of Molecular Sciences·Rita MorettiClaudio Tiribelli
Aug 28, 2021·International Journal of Molecular Sciences·Shao-Chun WuChing-Hua Hsieh

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Methods Mentioned

BETA
amputation
GTPase
GTPases
nucleotide exchange

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