Small GTPases in peroxisome dynamics

Biochimica Et Biophysica Acta
Wilhelm W Just, Johan Peränen

Abstract

In this review article, we summarize current knowledge on peroxisome biogenesis/functions and the role that small GTPases may play in these processes. Precise intracellular distribution of cell organelles requires their regulated association to microtubules and the actin cytoskeleton. In this respect, RhoGDP/RhoGTP favor binding of peroxisomes to microtubules and actin filaments. In its GTP-bound form, RhoA activates a regulatory cascade involving Rho kinaseII and non-muscle myosinIIA. Such interactions frequently depend on phosphoinositides (PIs) of which PI4P, PI(4,5)P2, and PI(3,5)P2 were found to be present in the peroxisomal membrane. PIs are pivotal determinants of intracellular signaling and known to regulate a wide range of cellular functions. In many of these functions, small GTPases are implicated. The small GTPase ADP-ribosylation factor 1 (Arf1), for example, is known to stimulate synthesis of PI4P and PI(4,5)P2 on the Golgi to regulate protein and lipid sorting. In vitro binding assays localized Arf1 and the COPI complex to peroxisomes. In light of the recent discussion of pre-peroxisomal vesicle generation at the ER, peroxisomal Arf1-COPI vesicles may serve retrograde transport of ER-resident components. A mass sp...Continue Reading

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Citations

Feb 7, 2016·Biochimica Et Biophysica Acta·Ralf Erdmann
Apr 30, 2016·Current Opinion in Cell Biology·Barbara Knoblach, Richard A Rachubinski
Mar 8, 2018·Cells·Bor Luen Tang
Jan 11, 2020·FEMS Yeast Research·Minoska ValliDiethard Mattanovich
Oct 3, 2018·Biomedical Reports·Yoonjae ShinJong-Soo Chang
May 1, 2021·Cells·Mitzuko Dautt-CastroSergio Casas-Flores

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