PMID: 6411525Sep 1, 1983Paper

Small intestinal absorption of amino acids and a dipeptide in pancreatic insufficiency

Gut
P J MillaJ T Harries

Abstract

In this study a perfusion technique has been used to investigate in vivo jejunal absorption and transmural potential difference evoked by the neutral amino acids phenylalanine (56 or 20 mmol/l) and glycine (20 mmol/l), the dibasic amino acid lysine (56 or 5 mmol/l), and a dipeptide glycyl-l-phenylalanine (20 mmol/l) in 11 children with pancreatic insufficiency due to cystic fibrosis and in three children with other causes of exocrine pancreatic insufficiency. Net absorption and potential difference evoked by phenylalanine in both cystic fibrosis and pancreatic insufficiency, and net absorption of glycine in cystic fibrosis were significantly reduced; but the absorption of lysine and glycyl-l-phenylalanine was normal. Absorption of the constituent amino acids from the dipeptide was normal or increased in cystic fibrosis. Thus, these studies show a defect in active absorption of neutral amino acids in cystic fibrosis with pancreatic insufficiency and exocrine pancreatic insufficiency. We speculate that pancreatic factors participate in neutral amino acid absorption.

References

Nov 1, 1977·Archives of Disease in Childhood·J P McCollumJ T Harries
Jul 1, 1976·Annals of Clinical Biochemistry·P F Dixon, M S Stoll
Oct 1, 1975·Physiological Reviews·D M Matthews
Feb 1, 1976·The Journal of Pediatrics·C L MorinA Bonin
Apr 1, 1968·Metabolism: Clinical and Experimental·S J Saunders, R E Kirsch
May 1, 1980·Archives of Disease in Childhood·P J AggettJ T Harries

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Citations

Mar 29, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·B TóthG Breves
Mar 4, 1989·Lancet·P S BaxterC J Taylor
Jul 3, 1998·Gastroenterology Clinics of North America·S A McClaveH L Snider
Apr 1, 1990·Acta paediatrica Scandinavica·J D Lloyd-StillH U Wessel
Jul 24, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Li Li, Shawn Somerset
Nov 26, 2016·Journal of the Science of Food and Agriculture·Serena De MariaPaola Maresca
Dec 1, 1989·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R R BrinsonW M Pitts
May 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·K Gardiner, A Barbul
Jan 1, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·S A McClaveL J Goldsmith
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·H S Heymans
Jan 31, 2002·World Journal of Gastroenterology : WJG·Q P Chen

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