Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients

Journal of Neurogastroenterology and Motility
Hea Jung SungMyung-Gyu Choi

Abstract

Patients undergoing cholecystectomy may have small intestinal bacterial overgrowth (SIBO). We investigated the prevalence and characteristics of SIBO in patients with intestinal symptoms following cholecystectomy. Sixty-two patients following cholecystectomy, 145 with functional gastrointestinal diseases (FGIDs), and 30 healthy controls undergoing hydrogen (H2)-methane (CH4) glucose breath test (GBT) were included in the study. Before performing GBT, all patients were interrogated using bowel symptom questionnaire. The positivity to GBT indicating the presence of SIBO, gas types and bowel symptoms were surveyed. Post-cholecystectomy patients more often had SIBO as evidenced by a positive (+) GBT than those with FGID and controls (29/62, 46.8% vs 38/145, 26.2% vs 4/30, 13.3%, respectively; P = 0.010). In the gas types, the GBT (H2) + post-cholecystectomy patients was significantly higher than those in FGIDs patients (P = 0.017). Especially, positivity to fasting GBT (H2) among the GBT (H2)+ post-cholecystectomy patients was high, as diagnosed by elevated fasting H2 level. The GBT+ group had higher symptom scores of significance or tendency in abdominal discomfort, bloating, chest discomfort, early satiety, nausea, and tenesmus t...Continue Reading

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Citations

Dec 5, 2015·Expert Review of Gastroenterology & Hepatology·Francesca Romana PonzianiAntonio Gasbarrini
Apr 1, 2017·Clinical Drug Investigation·Leon Fisher, Alexander Fisher
Feb 3, 2018·Journal of Gastroenterology and Hepatology·Dae Bum KimJi Min Lee
Nov 20, 2019·Journal of Neurogastroenterology and Motility·Giuseppe LosurdoAlfredo Di Leo
May 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ki-Hyun Ryu
Nov 14, 2018·Current Treatment Options in Gastroenterology·Ayesha ShahGerald J Holtmann
May 6, 2021·United European Gastroenterology Journal·Uday C Ghoshal
Oct 2, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Katelyn E MadiganRichard B Weinberg

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