Small intestinal bacterial overgrowth in patients suffering from scleroderma: clinical effectiveness of its eradication

The American Journal of Gastroenterology
Andrea ParodiMassimo Ghio

Abstract

After the skin, the gastrointestinal tract is the second most common target of systemic sclerosis (SSc). Our aims were to investigate orocecal transit time (OCTT) and the presence of small intestinal bacterial overgrowth (SIBO) in SSc as a cause of intestinal symptoms. Fifty-five SSc patients and 60 healthy controls, sex and age matched, entered the study. Enrolled subjects completed a questionnaire for intestinal symptoms and a global symptomatic score (GSS) was calculated. OCTT and the presence of SIBO were assessed by a lactulose breath test (LBT). Patients with SIBO were treated with rifaximin 1,200 mg/day for 10 days. Finally, a second questionnaire and LBT were performed 1 month after the end of therapy. The prevalence of SIBO was higher in SSc patients compared with controls (30/54 vs 4/60, respectively, P < 0.001). OCTT was significantly slower in SSc patients compared with controls (150 min, 25-75th percentile 142.5-165 vs 105 min, 25-75th percentile 90-135, respectively, P < 0.001). In patients with SIBO, the median GSS score was 8 (25-75th percentile 3.25-10.75). Eradication of SIBO was achieved in 73.3% of patients, with a significant reduction of symptoms in 72.7% of them (GSS score 2, 25-75th percentile 1-3, P < 0...Continue Reading

References

Jan 1, 1990·Gastroenterology·G CorazzaG Gasbarrini
Apr 1, 1995·Journal of Internal Medicine·E Husebye
Jun 12, 1999·Scandinavian Journal of Gastroenterology·M TrezzaS Laurberg
Jan 11, 2001·The American Journal of Gastroenterology·M PimentelH C Lin
Oct 3, 2002·Gastroenterology·Fiona GoldblattSally A Waterman
Dec 11, 2002·Best Practice & Research. Clinical Rheumatology·Gabriele Valentini, Carol Black
Jul 10, 2003·Autoimmunity Reviews·Chris T Derk, Sergio A Jimenez
Aug 19, 2004·JAMA : the Journal of the American Medical Association·Henry C Lin
Feb 5, 2005·Seminars in Arthritis and Rheumatism·Kanyakorn JaovisidhaKonrad H Soergel
Apr 7, 2005·Digestive Diseases and Sciences·Francesco Di MarioAngelo Franzé
Apr 28, 2005·Chemotherapy·Einar Husebye
Oct 11, 2005·European Journal of Gastroenterology & Hepatology·Kristina SjölundAnita Akesson
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael D LevittJohn Ruddy
Jul 14, 2006·Current Gastroenterology Reports·Hyo-Rang Lee, Mark Pimentel
Dec 13, 2006·La Presse médicale·Isabelle Marie
Jan 6, 2007·Histopathology·S R Owens, J K Greenson

❮ Previous
Next ❯

Citations

Aug 22, 2009·Rheumatology·Isabelle MarieHervé Levesque
Aug 2, 2012·Rheumatology·Elizabeth HarrisonSimon Lal
Feb 6, 2013·Rheumatology·Edoardo SavarinoAntonio Gasbarrini
Jun 24, 2010·World Journal of Gastroenterology : WJG·Jan BuresMarcela Kopacova
Nov 14, 2013·World Journal of Gastroenterology : WJG·Xin-Ping Tian, Xuan Zhang
May 24, 2011·Journal of Neurogastroenterology and Motility·Eamonn M M Quigley
Dec 5, 2015·Expert Review of Gastroenterology & Hepatology·Francesca Romana PonzianiAntonio Gasbarrini
May 16, 2009·Expert Opinion on Drug Metabolism & Toxicology·Veronica OjettiAntonio Gasbarrini
Jun 11, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Alexandra R Vaughn, Raja K Sivamani
Sep 3, 2013·Therapeutic Advances in Chronic Disease·Amit H Sachdev, Mark Pimentel
Dec 8, 2017·The American Journal of Gastroenterology·Ali RezaieSatish Rao
Oct 17, 2009·The Journal of Rheumatology·Murray BaronUNKNOWN Canadian Scleroderma Research Group
Nov 2, 2018·Archives of Dermatological Research·Beata Polkowska-PruszyńskaDorota Krasowska
Sep 2, 2016·The American Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Jul 24, 2018·Expert Opinion on Drug Safety·Edoardo SavarinoVincenzo Savarino
Oct 17, 2014·Annals of Clinical Microbiology and Antimicrobials·Doron BoltinRam Dickman
Nov 14, 2012·Nature Reviews. Rheumatology·Zsuzsanna H McMahan, Laura K Hummers
Jul 7, 2016·Nature Reviews. Gastroenterology & Hepatology·Anton Emmanuel
May 26, 2015·Current Treatment Options in Rheumatology·Vivek NagarajaDinesh Khanna
Jun 18, 2019·The American Journal of Gastroenterology·Paul T KrönerBrian E Lacy
Oct 5, 2019·Clinical and Translational Gastroenterology·Satish S C Rao, Jigar Bhagatwala
Jul 19, 2017·Current Opinion in Rheumatology·Elizabeth R Volkmann
Jan 11, 2016·Arthritis & Rheumatology·Elizabeth R VolkmannJonathan Braun
May 21, 2020·International Journal of Molecular Sciences·Giuseppe LosurdoAlfredo Di Leo
Dec 13, 2016·Annals of the Rheumatic Diseases·Otylia Kowal-BieleckaUNKNOWN EUSTAR Coauthors
Jan 13, 2015·European Radiology·Edoardo SavarinoLuca Maria Sconfienza
Feb 8, 2019·International Journal of Rheumatic Diseases·Kookwan SawadpanichChingching Foocharoen
Jan 31, 2017·Journal of Scleroderma and Related Disorders·Andrew B ShreinerDinesh Khanna
Aug 25, 2017·Journal of Immunology Research·Rossella TalottaPiercarlo Sarzi-Puttini
Oct 20, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Melissa A NicklesRaja K Sivamani
Jan 21, 2021·Advances in Rheumatology·Simon ParreauAnne-Laure Fauchais
Jan 30, 2021·Computational and Structural Biotechnology Journal·Chris CallewaertBernhard Paetzold
Feb 20, 2021·Current Opinion in Gastroenterology·Stefania Chetcuti Zammit, Reena Sidhu
Jul 27, 2021·Current Treatment Options in Gastroenterology·Z H McMahan, D Khanna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.