Small intestinal bacterial overgrowth: histopathologic features and clinical correlates in an underrecognized entity.

Archives of Pathology & Laboratory Medicine
Paul J LappingaTsung-Teh Wu

Abstract

Small intestinal bacterial overgrowth (SIBO) is a common cause of chronic diarrhea and malabsorption. Morphologic changes associated with this condition have not, to our knowledge, been studied in detail. To better characterize the histopathologic changes associated with SIBO by comparing the clinicopathologic features of patients with SIBO (duodenal aspirate cultures with > or =10(5) colony-forming units [CFUs]/mL) to controls with cultures found to be negative (<10(5) CFUs/mL). We included 67 consecutive patients with SIBO and 55 controls in the series. Each duodenal biopsy was assessed for the following features: villous to crypt ratio, intraepithelial lymphocytosis, crypt apoptoses, basal plasmacytosis, cryptitis/villitis, peptic duodenitis, erosions/ulcers, eosinophilia, and absence of goblet and Paneth cells; and correlated with clinical features and culture results. Decreased villous to crypt ratio (<3ratio1) was more frequent in SIBO than controls (24% versus 7%; P = .01). Duodenal biopsies from patients with SIBO were slightly less likely to be judged within reference range than were controls (52% versus 64%; P = .27). There were no significant differences in any of the other histologic features. Clinically, patients i...Continue Reading

References

Jul 1, 1992·Journal of the American Geriatrics Society·I P DonaldR M Kupfer
Jul 1, 1995·Scandinavian Journal of Gastroenterology·S M RiordanT D Bolin
Apr 16, 1998·Digestive Diseases and Sciences·J SuD Morrow
Dec 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·U Fagundes-NetoI C Scaletsky
Jan 11, 2001·The American Journal of Gastroenterology·M PimentelH C Lin
Mar 10, 2001·The American Journal of Gastroenterology·S M RiordanT D Bolin
Mar 26, 2002·Digestive Diseases and Sciences·Daniel MishkinSeymour Mishkin
May 22, 2003·Journal of the American Geriatrics Society·Alexandr ParlesakChristiane Bode
Jun 24, 2003·The American Journal of Gastroenterology·Steingerdur Anna GunnarsdottirEinar S Björnsson
May 1, 2004·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·B LoboJ R Malagelada
Jul 10, 2004·Journal of Gastroenterology and Hepatology·Marcus TeoAdrian Cummins
May 11, 2005·World Journal of Gastroenterology : WJG·Antonio TursiWalter Elisei
Feb 14, 2006·Gut·M Simrén, P-O Stotzer
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Jacqueline L FridgeKenneth Cox
Mar 21, 2007·Digestive Diseases and Sciences·Jairo César dos ReisUlysses Fagundes-Neto
Apr 5, 2007·The Journal of Clinical Endocrinology and Metabolism·Eugenia ResminiDiego Ferone
May 17, 2007·The American Journal of the Medical Sciences·Marek MajewskiRichard W McCallum
Aug 19, 2007·The Journal of Clinical Endocrinology and Metabolism·Ernesto Cristiano LauritanoAntonio Gasbarrini
Oct 16, 2007·Digestive Diseases and Sciences·Robyn DomsicKlaus Bielefeldt
Dec 27, 2007·Cancer Biotherapy & Radiopharmaceuticals·Mikael GunnarssonSören Mattsson

❮ Previous
Next ❯

Citations

Jun 11, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Zev H DavidovicsJames Versalovic
Dec 18, 2018·European Journal of Gastroenterology & Hepatology·Annalisa SchiepattiFederico Biagi
May 3, 2016·Therapeutic Advances in Gastroenterology·Dietmar EnkoGernot Kriegshäuser
Apr 14, 2020·European Journal of Gastroenterology & Hepatology·Annalisa SchiepattiFederico Biagi
May 25, 2021·Gastroenterology Clinics of North America·Daniel Bushyhead, Eamonn M Quigley
Aug 18, 2017·Clinical and Translational Gastroenterology·Amrit K Kamboj, Amy S Oxentenko
Jun 11, 2021·Frontiers in Endocrinology·Biao WangYanjie Ban
Jul 22, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Biren P ModiPaul W Wales
May 18, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro Lugli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.