PMID: 2500046Jul 1, 1989Paper

Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy

Annals of Internal Medicine
R UllrichE O Riecken

Abstract

To determine small intestinal mucosal structure and function in patients with human immunodeficiency virus (HIV) infection. Prospective, consecutive sample study. Referral-based medical clinics at a municipal and a university medical center. Forty-five HIV-infected patients (44 men, 1 woman) with gastrointestinal complaints. All patients had esophagogastroduodenoscopy. Distal duodenal biopsy samples were examined morphometrically and by quantitative enzyme histochemical techniques. Immunohistologic studies were done to determine whether HIV antigen p24 was present. Biopsy and stool samples were examined for enteric pathogens and patients were evaluated for malabsorption. Malabsorption was common in HIV-infected patients. In 15 of 38 patients mononuclear cells infected with HIV were found in the mucosa. In 15 of 25 patients there was no detectable lactase (beta-glucosidase) activity in the duodenal brush border; when measurable, lactase (beta-glucosidase) activity was decreased (P less than 0.02). Alkaline phosphatase activity was normal. Crypt depth was greater (P less than 0.05), villous surface area was slightly smaller, and mitotic figures per crypt were not different in HIV-infected patients compared with controls. Patients...Continue Reading

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·T SchneiderM Zeitz
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