Small intestinal submucosa does not promote PAIII tumor growth in Lobund-Wistar rats

The Journal of Surgical Research
Jason P HoddeMichael C Hiles

Abstract

Site-specific remodeling and angiogenesis are two observations associated with the use of small intestinal submucosa (SIS) as a tissue repair graft. Its angiogenic capacity has raised questions concerning its effect on tumor growth and metastasis in clinical tumor resection cases. The effect of SIS on the ability of neoplastic (prostate adenocarcinoma) cells to establish, grow, and metastasize was examined in Lobund-Wistar (L-W) rats. In one study, SIS, expanded polytetrafluoroethylene (ePTFE), or human cadaveric dermis was placed in a subcutaneous pocket on the flank of L-W rats and immediately inoculated with PA-III cell suspension. Tumors were allowed to establish and metastasize for 5 weeks prior to sacrifice. Rate of tumor growth, tumor weight, and frequency of lung metastases were assessed. In a second study, SIS was placed in a resected tumor bed and tumors were allowed to recur. Rate of tumor growth, tumor weight, and frequency of lung metastases were assessed after 3 weeks. ePTFE hastened the rate of formation of palpable tumors compared to controls and other materials; cadaveric dermis and SIS did not. No differences between materials were noted in final tumor weight nor in the frequency of metastasis to the lungs. Fo...Continue Reading

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Citations

Feb 5, 2010·The Laryngoscope·Sean R WeissEugene A Woltering
Sep 28, 2018·Tissue Engineering. Part a·Lindsey T SaldinStephen F Badylak
Dec 16, 2015·Applied Developmental Science·Peter C ScalesTravis J Pashak
Aug 25, 2005·Experimental Biology and Medicine·Morris Pollard, Mark A Suckow

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