PMID: 2717603Jan 1, 1989Paper

Small intestinal transit, bacterial growth, and bowel habits in diabetes mellitus

Pancreas
U SpenglerW Kruis

Abstract

To investigate diabetic alterations of small intestinal transit and bacterial growth, we performed hydrogen breath tests (10 g lactulose via duodenal tube at the ligament of Treitz), bacterial cultures, and determinations of unconjugated serum bile acids in 19 patients with long-standing diabetes and 7 healthy controls. Asymptomatic diabetics had a late rise in breath hydrogen, indicating prolonged jejunal-cecal transit (86 +/- 10 min, p less than 0.05) as an early pathogenic event. Rise in breath hydrogen in symptomatic diabetics (constipation: 50 +/- 6 min; diarrhea: 41 +/- 11 min) was not significantly different from controls (57 +/- 8 min). Bacterial studies and increased unconjugated serum bile acids suggest bacterial overgrowth in some symptomatic diabetics. Bacterial overgrowth was associated more frequently (p less than 0.05) with a rise in breath hydrogen before 45 min or after 75 min. Changes in the hydrogen breath test, bacterial growth, or unconjugated serum bile acids did not correlate with gastrointestinal symptoms of diabetes.

Citations

Oct 1, 1995·Diabetes/metabolism Reviews·V SpalloneG Menzinger
Jul 4, 2001·Gastroenterology Clinics of North America·P R Holt
Jan 7, 1999·Journal of Diabetes and Its Complications·A Spångéus, M El-Salhy
Oct 6, 1999·Journal of Diabetes and Its Complications·M El-Salhy
Apr 27, 2000·The New England Journal of Medicine·T M PetrilloS R Nesheim
Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·R CarratùF Prisco
Dec 1, 1993·Digestive Diseases and Sciences·S Y de BoerC B Lamers
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·S A Mitchell, R W Chapman
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·S Y de BoerC B Lamers
Apr 11, 1992·American Journal of Surgery·A M RozaM B Adams
Jul 26, 2006·The American Journal of Gastroenterology·Samuel H SigalElizabeth Ryan
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lizhen GuiMichael D Hughson
Oct 6, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jieyun Yin, Jiande Dz Chen
Jun 24, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Anne-Marie L WegebergAdam D Farmer
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Jul 1, 2020·Alimentary Pharmacology & Therapeutics·Christian LabenzMarcus-Alexander Wörns
Jun 1, 1992·Postgraduate Medicine·D K Beebe, E Walley

Related Concepts

Bile Salts
Colonic Inertia
Diabetes Mellitus
Nodular Glomerulosclerosis
Symmetric Diabetic Proximal Motor Neuropathy
Diabetic Retinopathy
Diarrhea
Duodenum
Paracolobactrum
Intestines, Small

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