PMID: 11340110May 8, 2001Paper

Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning

The Journal of Nutrition
M A SpreeuwenbergM W A Verstegen

Abstract

Compromising alterations in gastrointestinal architecture are common during the weaning transition of pigs. The relation between villous atrophy and epithelial barrier function at weaning is not well understood. This study evaluated in vitro transepithelial transport by Ussing metabolic chambers, local alterations in T-cell subsets and villous architecture at low energy intake level and their relation with lactose/protein ratios in the diet. Pigs (n = 66, 26 d old) were sampled either at weaning (d 0), d 1, 2 or 4 postweaning. Piglets received one of three diets at a low energy intake level, which differed in lactose and protein ratio as follows: low lactose/high protein (LL/HP), control (C), or high lactose/low protein (HL/LP). Mean digestible energy intake was 648 kJ/pig on d 1, 1668 kJ/pig on d 2, 1995 kJ/pig on d 3 and 1990 kJ/pig on d 4 postweaning. The CD4(+)/CD8(+) T-lymphocytes ratio decreased after weaning (P < 0.05). Decreased paracellular transport (P < 0.01), greater villous height (P < 0.01), shallower crypts and lower villus/crypt ratios (P < 0.01) were observed on d 2 compared with d 0. Piglets consuming the HL/LP diet tended to have less paracellular transport (P < 0.10) and greater villous height (P < 0.10) com...Continue Reading

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Citations

Feb 13, 2002·Journal of Pediatric Gastroenterology and Nutrition·Gaëlle BoudryBernard Sève
Dec 12, 2003·The British Journal of Nutrition·M A M Vente-SpreeuwenbergA C Beynen
Feb 10, 2011·The British Journal of Nutrition·Peter J A WijttenMartin W A Verstegen
Apr 1, 2010·Animal : an International Journal of Animal Bioscience·J KluessB G Miller
Feb 13, 2013·Journal of Animal Science·V T S RistR Mosenthin
Sep 1, 2010·International Health·Sue McKayRuud Albers
Oct 30, 2018·Journal of Animal Science·Hélène GilbertLucile Montagne
Jan 16, 2007·The British Journal of Nutrition·Lucile MontagneBernard Sève
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adam J MoeserAnthony T Blikslager
Jun 1, 2008·Animal : an International Journal of Animal Bioscience·G A WhiteJ Wiseman
Jan 25, 2011·Journal of Animal Science·P J A WijttenM W A Verstegen
May 15, 2015·BMC Veterinary Research·Nuria de Diego-CaberoIgnacio R Ipharraguerre
Apr 30, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Jun WangDe Wu
Mar 9, 2019·Frontiers in Veterinary Science·Xia XiongYanhong Liu
May 20, 2020·Porcine Health Management·Saranya NairRobert M Friendship
Jun 3, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Sabine Leonhard-MarekGerhard Breves
May 2, 2013·Journal of Animal Science and Biotechnology·Joy M CampbellJavier Polo
Sep 10, 2014·Functional & Integrative Genomics·Lorenzo BombaPaolo Ajmone-Marsan

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