PMID: 6410020Aug 1, 1983Paper

Small intestine of artificially reared rat pups: weight gain and changes in alkaline phosphatase, lactase and sucrase activities during development

The Journal of Nutrition
K Y Yeh

Abstract

Comparative studies on small intestinal development in artificially reared (AR) and in mother-fed (MF) rats were carried out. When pups at 12 days of age were reared by continuous intragastric infusing of a cow milk formula (CMF), they gained weight equal to MF rats until 20 days; their small intestine weight was approximately 40 and 23% greater than that of MF rats at 16 days and 22 days of age, respectively. Autoradiographic studies indicated that the intestinal DNA synthetic index was 74-85% higher in AR than in MF rats at 16 days; similarly intestinal crypt depth and duodenal villus length were significantly higher in AR rats. The developmental pattern of duodenal alkaline phosphatase activity was similar in both AR and MF rats. In contrast, AR rats showed precocious decrease of lactase activity in the ileum at 16 days and in the jejunum at 18 days; but total lactase activity in the intestine was not different from MF rats at 16 days. Jejunal sucrase activity in AR rats was precociously induced and elevated. It was concluded that the intestine of AR rats undergoes structural and enzymic modifications. The physiological significance of these changes remains to be elucidated.

Citations

Feb 1, 1986·The Proceedings of the Nutrition Society·S J Henning
May 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·F M ThompsonA G Cummins
Sep 22, 2010·Pediatric Research·Gaëlle BoudryIsabelle LE Huërou-Luron
Aug 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·B DvorakA F Philipps
Nov 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·L T WeaverC N Hales
May 11, 2010·Nutrition Research Reviews·Isabelle Le Huërou-LuronGaëlle Boudry
Mar 1, 1990·Developmental Psychobiology·E MooreE Murowchick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.