Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation.

Cell Cycle
Kristin MorethLiliana Schaefer

Abstract

Inflammation is not only a defensive mechanism against microbial invasion, but also frequently represents a critical response to tissue injury under sterile conditions. It is now well established that tissue injury leads to the release of endogenous molecules of intra- and extracellular origin acting as damage-associated molecular patterns (DAMPs). The small leucine-rich proteoglycans (SLRPs) can act as powerful DAMPs following their proteolytical release from the extracellular matrix. Recent investigations of SLRP signaling networks revealed new levels of complexity, showing that SLRPs can cluster different types of receptors and orchestrate a host of downstream signaling events. This review will summarize the evidence for the multifunctional proinflammatory signaling properties of the two archetypal SLRPs, biglycan and decorin. These secreted proteoglycans link the innate to the adaptive immune response and operate in a broad biological context, encompassing microbial defense, tumor growth and autoimmunity.

References

Nov 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P BiancoP G Robey
Feb 7, 1998·The Journal of Clinical Investigation·D K MoscatelloR V Iozzo
Feb 13, 1999·The Journal of Biological Chemistry·R V IozzoI Eichstetter
May 18, 2000·Journal of Neuroimmunology·A KikuchiI Kamo
Jul 18, 2000·The Journal of Biological Chemistry·I C ScottD S Greenspan
Jan 10, 2002·The Journal of Experimental Medicine·Christian TermeerJan Christoph Simon
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey B JohnsonJeffrey L Platt
Apr 30, 2003·The Journal of Biological Chemistry·Liliana SchaeferJosef Pfeilschifter
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Neeraj VijShukti Chakravarti
Feb 11, 2005·The Journal of Biological Chemistry·Elke SchönherrLiliana Schaefer
Jun 15, 2005·Annual Review of Biochemistry· InoharaGabriel Nuñez
Jul 19, 2005·The Journal of Clinical Investigation·Liliana SchaeferHermann-Josef Gröne
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja HilliardYouhai H Chen
Jan 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J BedkeH J Gröne
Mar 3, 2007·Annual Review of Biochemistry·Myeong Sup Lee, Young-Joon Kim
Apr 11, 2007·Current Opinion in Nephrology and Hypertension·Hans-Joachim Anders, Detlef Schlöndorff
Jul 10, 2007·The Journal of Biological Chemistry·Feng WuShukti Chakravarti
Sep 15, 2007·The Journal of Clinical Investigation·Huiling WuSteven J Chadban
Nov 3, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Dania MohtyPatrick Mathieu
Mar 15, 2008·Nature Reviews. Immunology·Hajime Kono, Kenneth L Rock
May 9, 2008·The Journal of Biological Chemistry·Liliana Schaefer, Renato V Iozzo
Aug 13, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Enrique BrandanCecilia Vial
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Silvia Goldoni, Renato V Iozzo
May 13, 2009·The Journal of Cell Biology·Silvia GoldoniRenato V Iozzo
Jun 11, 2009·Cell and Tissue Research·Liliana Schaefer, Roland M Schaefer
Jun 18, 2009·The Journal of Biological Chemistry·Seakwoo LeeShukti Chakravarti
Jul 17, 2009·The Journal of Biological Chemistry·Andrea BabelovaLiliana Schaefer
Oct 8, 2009·Journal of Cell Communication and Signaling·Rosetta MerlineLiliana Schaefer
Jan 19, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Sebastian Kalamajski, Ake Oldberg
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Jun 26, 2010·Nature Reviews. Immunology·Agnès LehuenAnne Cooke
Sep 25, 2010·Nature Reviews. Immunology·Lydia Sorokin

❮ Previous
Next ❯

Citations

Aug 29, 2013·Brain : a Journal of Neurology·Hannah BotfieldAnn Logan
Jun 16, 2012·American Journal of Respiratory Cell and Molecular Biology·Hui-Hua LiLi-Ming Zhang
Jul 24, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Madalina V NastaseLiliana Schaefer
Dec 25, 2013·PloS One·Osamu YamanakaWinston W-Y Kao
Mar 8, 2014·Journal of Cell Communication and Signaling·Sunil K Parapuram, William Hodge
Sep 18, 2013·Antioxidants & Redox Signaling·Johannes A Eble, Flávia Figueiredo de Rezende
Apr 12, 2014·Cell and Tissue Research·Sara GibertiniMarina Mora
May 31, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rui SongXianzhong Meng
Jul 16, 2014·Experimental Neurology·Andrew D Gaudet, Phillip G Popovich
Oct 21, 2014·The Journal of Clinical Investigation·Anna JonasMelissa Gresle
Dec 17, 2014·Expert Review of Anticancer Therapy·Khan ShahanavajChristian Rolfo
Feb 19, 2016·Journal of Anatomy·Alanna StanleyFabio Quondamatteo
Apr 11, 2015·Critical Reviews in Biochemistry and Molecular Biology·Clare E BryantKim S Midwood
Nov 3, 2015·Advanced Drug Delivery Reviews·Thomas NeillRenato V Iozzo
Apr 19, 2015·Journal of Molecular and Cellular Cardiology·Loren E DupuisChristine B Kern
Sep 17, 2015·American Journal of Medical Genetics. Part a·Andreas R JaneckeBeat Steinmann
Nov 6, 2012·Cellular Signalling·Maulilio John KipanyulaArmel Hervé Nwabo Kamdje
Jan 29, 2013·The FEBS Journal·Andrea MorrioneRenato V Iozzo
Jun 17, 2016·Molecular & Cellular Oncology·Thomas NeillRenato V Iozzo
Feb 11, 2014·Biochimica Et Biophysica Acta·Madalina V NastaseLiliana Schaefer
May 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Liliana Schaefer
Dec 24, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Jinyang Zeng-BrouwersLiliana Schaefer
Jan 1, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Zhiping WuBeatrice E Lechner
Feb 11, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Hannu JärveläinenThomas N Wight
Feb 24, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Renato V Iozzo, Liliana Schaefer
Jul 16, 2015·Biochemistry·Thomas NeillRenato V Iozzo
May 8, 2014·Mediators of Inflammation·Hana KolářováLukáš Kubala
Feb 18, 2015·Osteoarthritis and Cartilage·L XuG-X Ni
Nov 8, 2014·Biomaterials Science·Megan E SmithmyerApril M Kloxin
Mar 18, 2015·PloS One·Koshiro UedaKimikazu Hamano
Aug 16, 2016·Journal of Molecular and Cellular Cardiology·Renáta GáspárTamás Csont
Aug 20, 2016·Nature Reviews. Rheumatology·William H RobinsonJeremy Sokolove
Oct 20, 2015·Journal of Internal Medicine·A Hultgårdh-NilssonS Chakravarti
Oct 19, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Maria A GubbiottiRenato V Iozzo
Oct 30, 2016·Journal of Molecular and Cellular Cardiology·Nadine BeetzLutz Hein
Nov 20, 2016·The FEBS Journal·Liliana SchaeferRenato V Iozzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of the American Society of Nephrology : JASN
Liliana Schaefer
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Madalina V NastaseLiliana Schaefer
© 2021 Meta ULC. All rights reserved