Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging

Scientific Reports
James F HainfeldHenry M Smilowitz

Abstract

Standard clinical X-ray contrast agents are small iodine-containing molecules that are rapidly cleared by the kidneys and provide robust imaging for only a few seconds, thereby limiting more extensive vascular and tissue biodistribution imaging as well as optimal tumor uptake. They are also not generally useful for preclinical microCT imaging where longer scan times are required for high resolution image acquisition. We here describe a new iodine nanoparticle contrast agent that has a unique combination of properties: 20 nm hydrodynamic diameter, covalent PEG coating, 40 hour blood half-life, 50% liver clearance after six months, accumulation in tumors, and well-tolerated to at least 4 g iodine/kg body weight after intravenous administration in mice. These characteristics are unique among the other iodine nanoparticles that have been previously reported and provide extended-time high contrast vascular imaging and tumor loading. As such, it is useful for preclinical MicroCT animal studies. Potential human applications might include X-ray radiation dose enhancement for cancer therapy and vascular imaging for life-threatening situations where high levels of contrast are needed for extended periods of time.

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Citations

Oct 6, 2019·Scientific Reports·Yaser Hadi GholamiZdenka Kuncic
Sep 3, 2020·Nanomaterials·Sarkar Siddique, James C L Chow
Sep 26, 2020·Scientific Reports·James F HainfeldHenry M Smilowitz
Dec 29, 2020·Review Journal of Chemistry·D N MakhayevaV V Khutoryanskiy

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Methods Mentioned

BETA
X-ray
electron
dynamic light scattering

Software Mentioned

GraphPad Prism
Amira

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