Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

Gut
Huikuan ChuBernd Schnabl

Abstract

The spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from simple hepatic steatosis, commonly associated with obesity, to non-alcoholic steatohepatitis, which can progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD pathophysiology involves environmental, genetic and metabolic factors, as well as changes in the intestinal microbiota and their products. Dysfunction of the intestinal barrier can contribute to NAFLD development and progression. Although there are technical limitations in assessing intestinal permeability in humans and the number of patients in these studies is rather small, fewer than half of the patients have increased intestinal permeability and translocation of bacterial products. Microbe-derived metabolites and the signalling pathways they affect might play more important roles in development of NAFLD. We review the microbial metabolites that contribute to the development of NAFLD, such as trimethylamine, bile acids, short-chain fatty acids and ethanol. We discuss the mechanisms by which metabolites produced by microbes might affect disease progression and/or serve as therapeutic targets or biomarkers for NAFLD.

References

Feb 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Z M Yao, D E Vance
Oct 1, 1987·British Journal of Anaesthesia·J G KennaR Williams
Mar 1, 1970·The Biochemical Journal·M J WeidemannH A Krebs
Apr 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·M SandlerG M Stern
May 1, 1997·Journal of Gastroenterology and Hepatology·J LudwigK D Lindor
May 21, 1999·Science·D J ParksJ M Lehmann
Jun 9, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·K Watanabe-SuzukiO Suzuki
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·C S Lieber
Apr 2, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Judy L RaucyVeronica Zoleta
May 18, 2004·The Journal of Clinical Investigation·Mitsuhiro WatanabeJohan Auwerx
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yanqiao ZhangPeter A Edwards
Jul 11, 2006·The Journal of Clinical Investigation·Yun Chau Long, Juleen R Zierath
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc-Emmanuel DumasJeremy K Nicholson
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
May 10, 2008·European Journal of Gastroenterology & Hepatology·Márcia M AranhaCecília M P Rodrigues
May 13, 2008·Biochemical and Biophysical Research Communications·Verena KeitelDieter Häussinger
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Buck S SamuelJeffrey I Gordon
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriArun J Sanyal
Apr 29, 2010·Metabolism: Clinical and Experimental·Satish C KalhanMike Milburn
May 13, 2010·Digestive Diseases·Christopher Paul Day
Jul 20, 2010·The Surgical Clinics of North America·Sherif R Z Abdel-Misih, Mark Bloomston
Aug 25, 2010·Microbial Ecology·Ana DurbánAndrés Moya
Sep 30, 2010·Diabetes Care·Giovanni MussoMaurizio Cassader
Oct 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mikael BjursellMohammad Bohlooly-Y
Dec 15, 2010·Journal of Hepatology·Thijs W H PolsKristina Schoonjans
Jun 21, 2011·Annual Review of Microbiology·Jens Walter, Ruth Ley
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Gianluca Svegliati-BaroniAmalia Gastaldelli

❮ Previous
Next ❯

Citations

Jun 21, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Christelle KnudsenNathalie M Delzenne
Aug 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhanguo LiuPeng Chen
Aug 25, 2019·Current Gastroenterology Reports·Tien S DongShehnaz K Hussain
Dec 17, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Juan P ArabVijay H Shah
Jan 17, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Sonja LangBernd Schnabl
Jul 26, 2019·Rapid Communications in Mass Spectrometry : RCM·Wei-Kai WuMing-Shiang Wu
Nov 12, 2019·Clinical Liver Disease·Eamonn M M Quigley
Apr 21, 2020·Expert Review of Gastroenterology & Hepatology·Patrice D Cani, Matthias Van Hul
Nov 23, 2018·Gut·Marie JoossensGriet Glorieux
May 23, 2020·Inflammatory Bowel Diseases·Yejoo Jeon, Berkeley N Limketkai
May 23, 2019·World Journal of Gastroenterology : WJG·Da Zhou, Jian-Gao Fan
Aug 6, 2019·Journal of Clinical Biochemistry and Nutrition·Chihiro UshirodaYoshito Itoh
Aug 24, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fei ChenMohammed Eslam
Mar 11, 2020·Nature Reviews. Gastroenterology & Hepatology·Judith Aron-WisnewskyKarine Clément
May 12, 2020·World Journal of Gastroenterology : WJG·Hui-Ting ChenYong-Jian Zhou
Aug 23, 2020·International Journal of Molecular Sciences·Gianluca Svegliati-BaroniAmalia Gastaldelli
Aug 28, 2020·Frontiers in Medicine·Xiaofan JiangXin Guo
Jan 12, 2020·Journal of Cellular and Molecular Medicine·Xiaolin WangQing Xie
Mar 24, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Qingqing LvDifei Wang
Jun 26, 2020·Molecular Nutrition & Food Research·Bei GaoBernd Schnabl
Jan 24, 2019·World Journal of Gastroenterology : WJG·Naoki TanakaEiji Tanaka
Aug 21, 2019·International Journal of Molecular Sciences·Adriana FontesAnabela Marisa Azul
Jun 12, 2020·Chinese Journal of Integrative Medicine·Hong-Shan Li, Yi-Yang Hu
Feb 6, 2019·BioMed Research International·Gemma AragonèsTeresa Auguet
Jan 5, 2019·Infectious Diseases and Therapy·Berend J van WelzenJoop E Arends
Jul 31, 2019·International Journal of Molecular Sciences·Xiang Li, Lu Qi
Mar 14, 2020·PloS One·Tom DiedrichJulian Schulze Zur Wiesch
Oct 11, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Toon J I De MunckGer H Koek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

World Journal of Gastroenterology : WJG
Nur Arslan
Current Opinion in Gastroenterology
Katharina Brandl, Bernd Schnabl
Molecular Metabolism
Stavros BashiardesEran Elinav
Microbiology Spectrum
Anne-Marie CassardGabriel Perlemuter
Gastroenterología y hepatología
Marta Cobo MartínJavier Crespo
© 2022 Meta ULC. All rights reserved