Small molecule diselenide additives for in vitro oxidative protein folding

Chemical Communications : Chem Comm
Post Sai Reddy, Norman Metanis

Abstract

The in vitro oxidative folding of disulfide-rich proteins can be challenging. Here we show a new class of small molecule diselenides, which can be easily prepared from inexpensive starting materials, used to enhance oxidative protein folding. These compounds were tested on a model protein, bovine pancreatic trypsin inhibitor. Two of the tested diselenides showed considerable improvement over glutathione and were on par with the previously described selenoglutathione.

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Citations

Jun 29, 2016·Organic & Biomolecular Chemistry·Michal S ShoshanNorman Metanis
Dec 7, 2018·Chemical Communications : Chem Comm·Shunsuke OkadaTakahiro Muraoka
Dec 3, 2017·Chembiochem : a European Journal of Chemical Biology·Kenta AraiMichio Iwaoka
Sep 1, 2017·Angewandte Chemie·Reem MousaNorman Metanis
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenta Arai, Michio Iwaoka
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shunsuke OkadaTakahiro Muraoka
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zongcheng WangYuren Jiang
Oct 1, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Aditya UpadhyaySangit Kumar

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