Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications.

Chemical Science
Mingwang YangXiaojun Peng

Abstract

Endogenous gaseous signaling molecules including nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) have been demonstrated to perform significant physiological and pharmacological functions and are associated with various diseases in biological systems. In order to obtain a deeper insight into their roles and mechanisms of action, it is desirable to develop novel techniques for effectively detecting gaseous signaling molecules. Small-molecule fluorescent probes have been proven to be a powerful approach for the detection and imaging of biological messengers by virtue of their non-invasiveness, high selectivity, and real-time in situ detection capability. Based on the intrinsic properties of gaseous signaling molecules, numerous fluorescent probes have been constructed to satisfy various demands. In this perspective, we summarize the recent advances in the field of fluorescent probes for the detection of NO, CO and H2S and illustrate the design strategies and application examples of these probes. Moreover, we also emphasize the challenges and development directions of gasotransmitter-responsive fluorescent probes, hoping to provide a general implication for future research.

References

Feb 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stefan W Ryter, Leo E Otterbein
Mar 18, 2005·Journal of the American Chemical Society·Eita SasakiTetsuo Nagano
Oct 16, 2007·Chemistry, an Asian Journal·Justin T Mohr, Brian M Stoltz
Oct 25, 2007·Biochemical Society Transactions·L Li, P K Moore
Apr 21, 2009·Journal of Pharmaceutical and Biomedical Analysis·M PlazaE Ibáñez
May 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Erwan GalardonIsabelle Artaud
Jul 20, 2010·Annual Review of Analytical Chemistry·Evan M Hetrick, Mark H Schoenfisch
Aug 3, 2010·Journal of the American Chemical Society·Youjun YangJason B Shear
Jan 19, 2011·Chemical Communications : Chem Comm·Biplab MondalApurba Kalita
Sep 8, 2011·Inorganic Chemistry·Michael D PluthStephen J Lippard
Oct 13, 2011·Nature Communications·Yong QianChuan He
Oct 18, 2011·Journal of the American Chemical Society·Kiyoshi SasakuraTetsuo Nagano
Dec 14, 2011·Journal of the American Chemical Society·Lin YuanSasa Zhu
May 2, 2012·Respiratory Physiology & Neurobiology·Kenneth R OlsonSteve F Perry
Aug 28, 2012·Current Opinion in Chemical Biology·Vivian S Lin, Christopher J Chang
Sep 14, 2012·Journal of the American Chemical Society·Brian W MichelChristopher J Chang
Jan 22, 2013·Chemical Society Reviews·Zhipeng LiuZijian Guo
Dec 10, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Rabiul AlamMahammad Ali
Dec 18, 2013·Analytical Chemistry·Xiaohu DongZhihong Liu
Jun 3, 2014·Chemical Communications : Chem Comm·Xin LvWei Guo
Mar 31, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Beata Olas
Apr 22, 2015·British Journal of Pharmacology·Andreas PapapetropoulosPéter Ferdinandy
Jul 15, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Stefan W Ryter, Augustine M K Choi
Mar 5, 2016·Chemistry : a European Journal·Baogang WangTing Wang
May 14, 2016·Analytical Chemistry·Leticia A Montoya, Michael D Pluth
Jul 5, 2016·Advanced Drug Delivery Reviews·Yun Qian, John B Matson
Nov 2, 2016·Analytical Chemistry·Weiyong FengGuoqiang Feng
Jan 20, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Maria StrianeseClaudio Pellecchia
Jul 25, 2017·Chemical Communications : Chem Comm·Nithya VelusamySankarprasad Bhuniya

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Citations

Sep 26, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Pengjuan SunJing Liu
Oct 10, 2020·Chemistry, an Asian Journal·Xueqian ChenDongdong Su
Jan 14, 2021·Chemistry, an Asian Journal·Sujay MukhopadhyayKoushik Dhara
Jan 27, 2021·Chemical Communications : Chem Comm·Chao GeYong Qian
Feb 10, 2021·Advanced Drug Delivery Reviews·Yingzhu ZhouRona Chandrawati
Feb 19, 2021·Chemical Communications : Chem Comm·Jinye NiuBo Tang
Oct 20, 2020·Medicinal Research Reviews·Achini K VidanapathiranaStephen J Nicholls
Oct 26, 2021·Chembiochem : a European Journal of Chemical Biology·Pankaj E HandeSantosh J Gharpure
Nov 10, 2021·Journal of Agricultural and Food Chemistry·Xiaoyan ZengGuang-Fu Yang

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Methods Mentioned

BETA
electron paramagnetic resonance
xenograft
fluorescence imaging
FRET

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