Small molecule matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a polymer matrix

Rapid Communications in Mass Spectrometry : RCM
Leonard J Soltzberg, Pina Patel

Abstract

We have employed a light-absorbing electrically conductive polymer as a matrix to determine the molecular mass of small organic molecules using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. This method, which is in contrast to the usual MALDI strategy for matrix selection in which a small molecule matrix is used with a high molecular mass analyte, addresses the problem of matrix interference which limits the usefulness of MALDI-TOF for small molecule analysis. Use of negative ion mode offers advantages for this application. Using this approach, we have obtained clean molecular ion mass spectra of small organic molecules in the mass range 100-300 Da.

Citations

Sep 29, 2007·Journal of the American Society for Mass Spectrometry·L J SoltzbergRichard Newman
Nov 6, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Eddy Wing Yin NgTerence Chuen Wai Poon
Feb 1, 2006·Expert Review of Proteomics·Andrew M Dattelbaum, Srinivas Iyer
Aug 14, 2008·Journal of Mass Spectrometry : JMS·Susanna VogliardiPietro Traldi
Feb 20, 2010·Mass Spectrometry Reviews·Jeroen J A van KampenTheo M Luider
Mar 5, 2014·Rapid Communications in Mass Spectrometry : RCM·Michał CegłowskiGrzegorz Schroeder
Jul 27, 2007·Rapid Communications in Mass Spectrometry : RCM·Muhammad Ahsan HashirGuenther K Bonn
Nov 23, 2007·Mass Spectrometry Reviews·Annette S FangJames N Kyranos
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Anuja Shreeram KulkarniKun Qian
Aug 9, 2018·Journal of the American Chemical Society·Kilian HoratzFranziska Lissel

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