Small-molecule pheromones and hormones controlling nematode development

Nature Chemical Biology
Rebecca A Butcher

Abstract

The existence of small-molecule signals that influence development in Caenorhabditis elegans has been known for several decades, but only in recent years have the chemical structures of several of these signals been established. The identification of these signals has enabled connections to be made between these small molecules and fundamental signaling pathways in C. elegans that influence not only development but also metabolism, fertility, and lifespan. Spurred by these important discoveries and aided by recent advances in comparative metabolomics and NMR spectroscopy, the field of nematode chemistry has the potential to expand dramatically in the coming years. This Perspective will focus on small-molecule pheromones and hormones that influence developmental events in the nematode life cycle (ascarosides, dafachronic acids, and nemamides), will cover more recent work regarding the biosynthesis of these signals, and will explore how the discovery of these signals is transforming our understanding of nematode development and physiology.

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Citations

Dec 7, 2017·Parasitology·Gustavo Salinas, Gastón Risi
Jan 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvain Darnet, Hubert Schaller
May 1, 2019·Parasites & Vectors·Guangxu MaRobin B Gasser
Sep 30, 2020·Journal of Neurogenetics·Caroline S Muirhead, Jagan Srinivasan
Mar 20, 2020·BMC Biology·Sider PenkovTeymuras V Kurzchalia
Jul 20, 2019·Nature Chemical Biology·Andreas H LudewigFrank C Schroeder
Mar 12, 2021·Genetics·Denise M FerkeyNoelle D L'Etoile
Oct 15, 2020·Journal of the American Chemical Society·Jason S HokiFrank C Schroeder
Jun 7, 2018·Analytical Chemistry·Marianna RossettiAlessandro Porchetta

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