Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives.

Cells
Artem BlagodatskiVladimir L Katanaev

Abstract

The Wnt signaling is one of the major pathways known to regulate embryonic development, tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway are a common cause of several types of cancer and other diseases, such as osteoporosis and rheumatoid arthritis. This makes Wnt signaling an important therapeutic target. Small molecule activators and inhibitors of signaling pathways are important biomedical tools which allow one to harness signaling processes in the organism for therapeutic purposes in affordable and specific ways. Natural products are a well known source of biologically active small molecules with therapeutic potential. In this article, we provide an up-to-date overview of existing small molecule modulators of the Wnt pathway derived from natural products. In the first part of the review, we focus on Wnt pathway activators, which can be used for regenerative therapy in various tissues such as skin, bone, cartilage and the nervous system. The second part describes inhibitors of the pathway, which are desired agents for targeted therapies against different cancers. In each part, we pay specific attention to the mechanisms of action of the natural products, to the models on which they we...Continue Reading

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Citations

May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Mariane B SordiPaul T Sharpe
Aug 24, 2021·Journal of Bone and Mineral Metabolism·Haoling ChenFang Huang

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