Small molecules and their controlled release that induce the osteogenic/chondrogenic commitment of stem cells

Biotechnology Advances
Yingjun WangXuetao Shi

Abstract

Stem cell-based tissue engineering plays a significant role in skeletal system repair and regenerative therapies. However, stem cells must be differentiated into specific mature cells prior to implantation (direct implantation may lead to tumour formation). Natural or chemically synthesised small molecules provide an efficient, accurate, reversible, and cost-effective way to differentiate stem cells compared with bioactive growth factors and gene-related methods. Thus, investigating the influences of small molecules on the differentiation of stem cells is of great significance. Here, we review a series of small molecules that can induce or/and promote the osteogenic/chondrogenic commitment of stem cells. The controlled release of these small molecules from various vehicles for stem cell-based therapies and tissue engineering applications is also discussed. The extensive studies in this field represent significant contributions to stem cell-based tissue engineering research and regenerative medicine.

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Citations

Jan 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Timea SpakovaJan Rosocha
Mar 21, 2017·Annals of the Rheumatic Diseases·Jun DaiHongwei Ouyang
May 19, 2018·Journal of Drug Targeting·Gaorui CaiDaping Wang
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Oct 30, 2020·Stem Cell Research & Therapy·Mahsa GhorbaninejadMohamadreza Baghaban Eslaminejad
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Mar 22, 2021·International Journal of Pharmaceutics·Hala JarrarMenemşe Gümüşderelioğlu
Aug 1, 2021·Journal of Biomedical Materials Research. Part a·Zachary T Berent, Amy J Wagoner Johnson

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