Small non-coding RNA and colorectal cancer

Journal of Cellular and Molecular Medicine
Hui ChenDeliang Liu

Abstract

Colorectal cancer (CRC) is the third most common malignance. Although great efforts have been made to understand the pathogenesis of CRC, the underlying mechanisms are still unclear. It is now clear that more than 90% of the total genome is actively transcribed, but lack of protein-coding potential. The massive amount of RNA can be classified as housekeeping RNAs (such as ribosomal RNAs, transfer RNAs) and regulatory RNAs (such as microRNAs [miRNAs], PIWI-interacting RNA [piRNAs], tRNA-derived stress-induced RNA, tRNA-derived small RNA [tRFs] and long non-coding RNAs [lncRNAs]). Small non-coding RNAs are a group of ncRNAs with the length no more than 200 nt and they have been found to exert important regulatory functions under many pathological conditions. In this review, we summarize the biogenesis and functions of regulatory sncRNAs, such as miRNAs, piRNA and tRFs, and highlight their involvements in cancers, particularly in CRC.

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Citations

Dec 1, 2019·Mutagenesis·Antonio FrancavillaAlessio Naccarati
May 20, 2020·International Journal of Cancer. Journal International Du Cancer·Tianyu ZengYongmei Yin
Feb 28, 2020·Experimental and Therapeutic Medicine·Zheng XiaoXi Zeng
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Jan 6, 2021·Translational Oncology·Lifeng DingGonghui Li
Apr 23, 2021·Interdisciplinary Sciences, Computational Life Sciences·Yajun LiuXinhong Hei
May 18, 2021·Non-coding RNA Research·Guannan DuYi Li
Jul 2, 2021·Cancer Cell International·Fatemeh SadoughiZatollah Asemi
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Jul 10, 2021·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Diego Guerra-AlmeidaRodrigo Nunes-da-Fonseca

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Methods Mentioned

BETA
PCR
nuclear translocation

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