PMID: 9160748May 16, 1997Paper

Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA

Cell
J NiM J Fournier

Abstract

Ten ACA yeast small nucleolar RNAs (snoRNAs) were shown to be required for site-specific synthesis of pseudouridine psi in ribosomal RNA. A common secondary folding motif for the snoRNAs and rRNA target segments predicts that site selection involves: (1) base pairing of the snoRNA with complementary rRNA elements flanking the site of modification, and (2) identification of a uridine located at a near-constant distance from the snoRNA ACA box. The model is supported by mutations showing that: (1) reducing the complementarity between the snoRNA and rRNA disrupts psi formation, and (2) altering the distance between the ACA box and target uridine causes an adjacent uridine to be modified. This discovery implies that most snoRNAs function in targeting nucleotide modification in rRNA: ribose methylation for the box C/D snoRNAs and psi formation for the ACA snoRNAs.

References

Jan 1, 1990·Progress in Nucleic Acid Research and Molecular Biology·B E Maden
Aug 1, 1988·Molecular and Cellular Biology·R ParkerC Guthrie
Jan 1, 1966·Progress in Nucleic Acid Research and Molecular Biology·E Goldwasser, R L Heinrikson
Jan 1, 1995·Annual Review of Biochemistry·E S Maxwell, M J Fournier
Jul 11, 1995·Nucleic Acids Research·D A SamarskyM J Fournier
Jul 1, 1995·Trends in Biochemical Sciences·J P BachellerieM J Fournier
Jan 1, 1994·Biochimie·J R Patton
Nov 25, 1993·Nucleic Acids Research·A G BalakinM J Fournier
Apr 1, 1993·Molecular and Cellular Biology·J P Morrissey, D Tollervey
Dec 1, 1995·Yeast·J Venema, D Tollervey
Nov 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J OfengandB G Lane
Oct 24, 1996·Nature·T Maden
Nov 1, 1996·Current Biology : CB·B A Peculis, S M Mount
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T TycowskiJ A Steitz

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Citations

Dec 16, 2006·Current Genetics·Andrea Hinas, Fredrik Söderbom
Mar 17, 2005·Chromosoma·U Thomas Meier
Dec 3, 2011·Molecular Genetics and Genomics : MGG·Ashley N Moore, Anthony G Russell
Aug 23, 2007·Plant Molecular Biology·Inna LermontovaIngo Schubert
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Rosario Machado-PinillaRosario Perona
Oct 7, 2011·Protein & Cell·Andrew T YuYi-Tao Yu
Jul 19, 2002·FEBS Letters·Xinyu Song, Ross N Nazar
Oct 24, 2001·Cell·J R Warner
Oct 19, 1999·Biochimica Et Biophysica Acta·A Rebane, A Metspalu
Nov 30, 2002·Biochimie·Jean Pierre BachellerieAlexander Hüttenhofer
Jul 8, 1999·Current Opinion in Cell Biology·L B Weinstein, J A Steitz
Jul 13, 2002·Trends in Biochemical Sciences·Wayne A Decatur, Maurille J Fournier
Jul 1, 1997·Trends in Biochemical Sciences·J P Bachellerie, J Cavaillé
Nov 12, 1998·Trends in Biochemical Sciences·D L Lafontaine, D Tollervey
Dec 16, 1998·Trends in Biochemical Sciences·B E Maden
Dec 14, 2011·ACS Chemical Biology·Kelly PhelpsPeter A Beal
Sep 1, 2006·Nature·Ling Li, Keqiong Ye
Dec 11, 2007·Nature Methods·Xinliang Zhao, Yi-Tao Yu
Mar 31, 2012·Nature Protocols·Chao HuangYi-Tao Yu
Nov 16, 2005·Nature Structural & Molecular Biology·Tomoko HammaAdrian R Ferré-D'Amaré
Dec 7, 2007·Nature Structural & Molecular Biology·Bo LiangHong Li
Oct 29, 2000·British Journal of Haematology·I Dokal
May 22, 2001·Molecular Microbiology·P P DennisT Lowe
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qi ZhangJuli Feigon

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