Small organic molecules that modulate gene transcription

Drug Discovery Today
Dongju JungMotonari Uesugi

Abstract

Regulation of gene expression by transcription factors touches all aspects of human biology and often induces extreme phenotypes. Its external, precise control by small organic molecules represents a challenge in chemistry and biology. Here, we summarize recent progress in the field, together with contributions from our laboratory. Small-molecule modulators of transcription, including small-molecule transcription factors could find their use in basic biological studies and therapeutic intervention.

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Citations

Feb 21, 2008·Cell Biochemistry and Biophysics·Kathryn J BrayerDavid J Segal
Dec 22, 2007·Expert Review of Anticancer Therapy·David P Turner, Dennis K Watson
Jun 21, 2011·Bioorganic & Medicinal Chemistry Letters·Kyung Hoon MinHyun-Ju Park
Sep 29, 2009·Bioorganic & Medicinal Chemistry Letters·Lori W LeeAnna K Mapp
Dec 24, 2011·Journal of the American Chemical Society·Chantal LangloisJames G Omichinski

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