Small Players Ruling the Hard Game: siRNA in Bone Regeneration

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Saber GhadakzadehMaryam Tabrizian

Abstract

Silencing gene expression through a sequence-specific manner can be achieved by small interfering RNAs (siRNAs). The discovery of this process has opened the doors to the development of siRNA therapeutics. Although several preclinical and clinical studies have shown great promise in the treatment of neurological disorders, cancers, dominant disorders, and viral infections with siRNA, siRNA therapy is still gaining ground in musculoskeletal tissue repair and bone regeneration. Here we present a comprehensive review of the literature to summarize different siRNA delivery strategies utilized to enhance bone regeneration. With advancement in understanding the targetable biological pathways involved in bone regeneration and also the rapid progress in siRNA technologies, application of siRNA for bone regeneration has great therapeutic potential. High rates of musculoskeletal injuries and diseases, and their inevitable consequences, impose a huge financial burden on individuals and healthcare systems worldwide.

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Citations

Jul 6, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Saber GhadakzadehReggie C Hamdy
Jun 26, 2017·Journal of Bone and Mineral Metabolism·Mohammad M AlzahraniReggie C Hamdy
Sep 6, 2018·Bone Research·Ming DangPeter X Ma
Jul 27, 2018·Frontiers of Medicine·Rui ShiWei Tian
Oct 10, 2020·International Journal of Immunopathology and Pharmacology·Jun WanShaodong Qiu
Jul 11, 2020·Biomedical Materials·Satheesh ElangovanAliasger K Salem
Aug 9, 2019·International Journal of Pharmaceutics·Pinpin WangChantal Pichon
Jun 26, 2021·Frontiers in Molecular Biosciences·Laila A Damiati, Sarah El-Messeiry

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