Small regulatory RNAs in Pseudomonas aeruginosa

RNA Biology
Elisabeth SonnleitnerUdo Bläsi

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa is frequently associated with nosocomial infections, and can be life threatening in immunosuppressed, cancer and cystic fibrosis patients. Virulence in P. aeruginosa is combinatorial, and results from the activation of several genetic programs that regulate motility, attachment to the host epithelium as well as the synthesis of exotoxins. The pathogen has a high survival capacity in the host owing to its metabolic versatility, nutrient scavenging and resistance against both, antibiotics and immune defenses. Adaptive responses to various environmental stresses and stimuli are often regulated by small regulatory RNAs (sRNA). In this review, we summarize the current knowledge on the regulation and function of P. aeruginosa sRNAs that titrate regulatory proteins, base-pair with target mRNAs, and which are derived from CRISPR elements.

References

Apr 1, 1990·Molecular Microbiology·M J WickB H Iglewski
Oct 1, 1996·Journal of Bacteriology·H Nikaido
Apr 3, 2001·Current Opinion in Microbiology·K Hantke
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eric Massé, Susan Gottesman
Apr 16, 2002·Molecular Microbiology·Ruud JansenLeo M Schouls
Oct 3, 2003·Microbial Pathogenesis·Elisabeth SonnleitnerUdo Bläsi
Jan 24, 2004·The EMBO Journal·Thomas A Geissmann, Danièle Touati
Mar 11, 2004·Molecular Microbiology·Poul Valentin-HansenChristina Udesen
Mar 20, 2004·The Journal of Biological Chemistry·Claudio ValverdeDieter Haas
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paula J WildermanMichael L Vasil
Oct 19, 2004·Annual Review of Microbiology·Susan Gottesman
Mar 29, 2005·Journal of Molecular Evolution·Francisco J M MojicaElena Soria
Oct 4, 2005·Journal of Bacteriology·Eric MasséSusan Gottesman
Nov 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth KayDieter Haas
Dec 20, 2005·Journal of Molecular Biology·Stephan HeebPaul Williams
Dec 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Isabelle VentreAlain Filloux
May 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eric E SmithMaynard V Olson
Jul 18, 2006·Nature Reviews. Microbiology·Laura J V Piddock
Aug 4, 2006·Journal of Bacteriology·Elisabeth KayDieter Haas
Sep 19, 2006·Nature Reviews. Microbiology·Alexei V Kazantsev, Norman R Pace
Sep 23, 2006·FEMS Microbiology Reviews·Vladimir R Kaberdin, Udo Bläsi
Dec 5, 2006·Biochemical and Biophysical Research Communications·Theresa Sorger-DomeniggUdo Bläsi
Dec 23, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Michael L Vasil
Feb 3, 2007·The EMBO Journal·Branislav VecerekUdo Bläsi
Mar 24, 2007·Science·Rodolphe BarrangouPhilippe Horvath
Mar 27, 2007·Current Opinion in Microbiology·Karen M Wassarman
Mar 27, 2007·Current Opinion in Microbiology·Paul Babitzke, Tony Romeo

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Citations

Nov 13, 2012·Nucleic Acids Research·Deepak BalasubramanianKalai Mathee
Apr 8, 2014·PloS One·Rajnikant SharmaRanjana Pathania
Feb 13, 2014·Applied Microbiology and Biotechnology·Zhen KangJian Chen
Jun 2, 2015·Biotechnology Advances·Amit Kumar ChaudharyEun Yeol Lee
Jul 30, 2014·Pathogens and Disease·Deepak BalasubramanianKalai Mathee
Jul 13, 2017·Microbiology·Elva Quiroz-RochaCinthia Nuñez
Nov 5, 2017·Biochemical Society Transactions·Erik Holmqvist, E Gerhart H Wagner
Dec 10, 2014·Journal of Bacteriology·Christopher L PritchettMichael J Schurr
Aug 28, 2019·World Journal of Microbiology & Biotechnology·Krishna Bharwad, Shalini Rajkumar
Sep 13, 2019·Nature Communications·Sara K ChuangZemer Gitai
Nov 27, 2019·Applied Microbiology and Biotechnology·Brenda KischkelMelyssa Negri
Nov 30, 2018·International Journal of Molecular Sciences·Tiago PitaJorge H Leitão
Jun 24, 2016·Microbiology Spectrum·Sarah L Svensson, Cynthia M Sharma
Aug 28, 2021·International Journal of Molecular Sciences·Petra PusicUdo Bläsi

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