Small renal masses initially managed using active surveillance: results from a retrospective study with long-term follow-up

Clinical Genitourinary Cancer
E BrunocillaG Martorana

Abstract

The purpose of this study was to provide outcomes of patients managed using active surveillance (AS) for small renal masses (SRMs). We retrospectively reviewed data of 62 patients diagnosed with 64 contrast enhancing SRMs suspicious for renal cell carcinoma. We evaluated the differences between patients who remained on AS and those who underwent delayed surgical intervention. The mean age of patients was 75 years and the mean follow-up was 91.5 months. The median tumor size and the median estimated tumor volume were 2.6 cm and 8.7 cm(3), respectively. The median linear growth rate and the median volumetric growth rate were 0.7 cm/y and 8.8 cm(3)/y, respectively. The mean linear and volumetric growth rates of the group of patients who underwent surgery was higher than in those who remained on surveillance (1.9 vs. 0.4 cm/y and 16.1 vs. 4.6 cm(3)/y, respectively; P < .001). Most SRMs show an indolent course, with low metastatic potential. Faster linear and volumetric growth rates could be the expression of malignant disease, thus suggesting the need for a delayed surgical intervention. AS is a reasonable option for the management of SRMs in properly selected patients with low life expectancy.

References

Nov 25, 2003·The Journal of Urology·Igor FrankHorst Zincke
Oct 21, 2005·Cancer Treatment Reviews·Beverly J Drucker
Aug 3, 2007·European Urology·Hendrik Van Poppel, Steven Joniau
Feb 24, 2010·World Journal of Urology·Mesut RemziMehmet Ozsoy
Mar 20, 2010·The Journal of Urology·Juan Carlos RosalesJaime Landman
Jul 17, 2010·European Urology·Börje LjungbergUNKNOWN European Association of Urology Guideline Group
Aug 3, 2011·Cleveland Clinic Journal of Medicine·Anil A Thomas, Steven C Campbell
Apr 21, 2012·Current Opinion in Urology·Stanley A YapAntonio Finelli
Jun 19, 2012·Current Opinion in Urology·Brian R LaneChristopher B Riedinger
Sep 11, 2012·European Urology·Sarah P PsutkaDebra A Gervais
Jan 31, 2013·International Urology and Nephrology·Eugenio BrunocillaGiuseppe Martorana
May 7, 2013·World Journal of Urology·Marco BorghesiVincenzo Ficarra

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Citations

Jun 11, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lei ZhangLiqun Zhou
Mar 18, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Marco BorghesiRiccardo Schiavina
May 8, 2015·Chinese Medical Journal·Lei ZhangLi-Qun Zhou
Dec 3, 2014·Clinical Genitourinary Cancer·Riccardo SchiavinaEugenio Brunocilla
Jun 23, 2016·Journal of Computer Assisted Tomography·Megha NayyarVinay Duddalwar
Jan 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio FinelliPaul Russo
Dec 19, 2017·Nephrology·Gaetano La MannaGiorgia Comai
Sep 1, 2017·Indian Journal of Surgical Oncology·Scott G ErpeldingRamakrishna Venkatesh
Oct 14, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Riccardo SchiavinaEugenio Brunocilla
Sep 8, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Giorgia ComaiGaetano La Manna
Nov 28, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P Mongiat-ArtusY Neuzillet

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