PMID: 2106385Mar 15, 1990Paper

Small testicles with impaired production of sperm in adult male survivors of childhood malignancies

Cancer
M A Siimes, J Rautonen

Abstract

Testicular size has been studied in 66 adult men who survived leukemia (n = 14) or cancer (n = 52) in childhood. Mean follow-up time was 14.5 years. The testicular size was measured as the length and breadth in mm; testicular volume index was calculated. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin were measured. A sperm sample was obtained from 46 men. The patients had smaller testicles than healthy medical students; 51 had small testicles. The size was the smallest in patients who survived leukemia. Multivariate analysis showed that the variables with independent effects on testicular size were cranial and testicular irradiation and therapy with cyclophosphamide. Sperm production was dependent on testicular size. We conclude that determination of serum FSH combined with testicular size may offer a practical approach for predicting the subsequent testicular damage in boys with malignancies.

References

Jul 26, 1975·Lancet·J D BuchananJ U Barrie
Mar 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F AubierJ Lemerle
Jun 1, 1988·The Journal of Pediatrics·P E ClaytonR H Campbell
Jan 1, 1988·Medical and Pediatric Oncology·N JaffeM da Cunha

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Citations

Mar 26, 1999·Cancer·P M LähteenmäkiM A Siimes
Nov 1, 1993·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·M A SiimesJ Rautonen
Jan 13, 2001·Molecular and Cellular Endocrinology·O Hovatta
Dec 1, 1996·Acta Paediatrica Japonica; Overseas Edition·H KobayashiM Hurusato
Oct 8, 1998·British Journal of Obstetrics and Gynaecology·G A Levitt, M E Jenney
Feb 1, 1992·Acta Psychiatrica Scandinavica·P RopponenV Aalberg
Jul 24, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria Alice Neves BordalloIlda Akemi Muramoto Alves Castilho
Sep 1, 2010·Radiology and Oncology·Lorna Zadravec ZaletelBerta Jereb
Jul 19, 2006·Asian Journal of Andrology·Theodoros MaltarisRalf Dittrich
Jun 9, 2007·Expert Review of Anticancer Therapy·Mohamed F M Mitwally
Feb 18, 2004·Pediatric Blood & Cancer·Julianne ByrneLeslie L Robison
Apr 24, 2008·Acta Paediatrica·P M LähteenmäkiJ Toppari
Apr 1, 1992·Surgical Oncology·F E JohnsonK C Tolman
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J RautonenM A Siimes
Jun 20, 2006·Reproductive Toxicology·Andrea GarollaCarlo Foresta
Aug 1, 1996·Hematology/oncology Clinics of North America·R M Lowenthal, K Eaton
Apr 7, 2005·The Lancet Oncology·W Hamish B WallaceD Stewart Irvine
Jul 6, 2000·Medical and Pediatric Oncology·T RelanderM Willén
Jan 1, 1996·Medical and Pediatric Oncology·S KlieschE Nieschlag
Feb 6, 2017·European Journal of Endocrinology·Wassim Chemaitilly, Laurie E Cohen
Feb 4, 2005·Human Reproduction·G BahadurD J Ralph
Oct 4, 2005·British Journal of Haematology·Mark F H Brougham, W H B Wallace
Oct 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Kirsi Jahnukainen, Jan-Bernd Stukenborg
Jul 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Charles A SklarM Hassan Murad
Jun 17, 1998·Journal of Pediatric Hematology/oncology·P ArikoskiH Kröger
Jun 30, 2004·Leukemia & Lymphoma·Lorna Zadravec ZaletelBerta Jereb
Feb 26, 2000·Pediatric Hematology and Oncology·J A López AndreuA Romeu
Dec 28, 1999·Human Reproduction·G Bahadur, P Hindmarsh
Jan 11, 2019·International Journal of Molecular Sciences·Yulia MichailovMahmoud Huleihel
Dec 21, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Hatem Soliman, Samuel V Agresta

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