Small thrombus size, thrombus composition, and poor collaterals predict pre-interventional thrombus migration.

Journal of Neurointerventional Surgery
Peter B SpornsUta Hanning

Abstract

Different imaging characteristics such as clot burden score, collaterals, and pre-interventional thrombus migration are associated with functional outcome in patients with acute ischemic stroke. Moreover, histological thrombus composition is associated with pre-interventional thrombus migration. We hypothesized that smaller clots may more likely migrate and that collateral status in ischemic stroke patients may mediate this tendency of the clot to migrate. In this prospective cohort of consecutive ischemic stroke patients, clot burden scores and collateral scores were rated and the retrieved thrombi were histologically analyzed. We then investigated the relationship between clot burden score, probability for thrombus migration, and collateral scores using mediation analysis. 163 patients are included of which 36 (22.1%) had a clot migration. Probability of thrombus migration was significantly associated with lower collateral scores (P<0.01), higher clot burden scores (P<0.01), shorter thrombi (P<0.01), and higher RBC count (P<0.01). In the mediator pathway, higher collateral scores were significantly associated with higher clot burden scores (P<0.01) and younger age (P=0.029). The total effect of an increase in clot burden scor...Continue Reading

References

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Jun 27, 2019·Journal of Neurointerventional Surgery·John Charles BensonWaleed Brinjikji
Jun 28, 2019·Stroke; a Journal of Cerebral Circulation·Peter B SpornsUta Hanning

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Citations

May 30, 2021·Journal of Neurointerventional Surgery·Yuko KataokaMasatoshi Koga
Jul 18, 2021·Journal of Neurointerventional Surgery·Lukas MeyerUNKNOWN TOPMOST Study Group

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