Abstract
Different imaging characteristics such as clot burden score, collaterals, and pre-interventional thrombus migration are associated with functional outcome in patients with acute ischemic stroke. Moreover, histological thrombus composition is associated with pre-interventional thrombus migration. We hypothesized that smaller clots may more likely migrate and that collateral status in ischemic stroke patients may mediate this tendency of the clot to migrate. In this prospective cohort of consecutive ischemic stroke patients, clot burden scores and collateral scores were rated and the retrieved thrombi were histologically analyzed. We then investigated the relationship between clot burden score, probability for thrombus migration, and collateral scores using mediation analysis. 163 patients are included of which 36 (22.1%) had a clot migration. Probability of thrombus migration was significantly associated with lower collateral scores (P<0.01), higher clot burden scores (P<0.01), shorter thrombi (P<0.01), and higher RBC count (P<0.01). In the mediator pathway, higher collateral scores were significantly associated with higher clot burden scores (P<0.01) and younger age (P=0.029). The total effect of an increase in clot burden scor...Continue Reading
References
Sep 1, 1987·Stroke; a Journal of Cerebral Circulation·I SaitoK Tsutsumi
Dec 1, 1986·Journal of Personality and Social Psychology·R M Baron, D A Kenny
Sep 25, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Volker PuetzUNKNOWN Calgary CTA Study Group
Jan 17, 2009·AJNR. American Journal of Neuroradiology·I Y L TanR I Aviv
Jul 28, 2012·AJNR. American Journal of Neuroradiology·M V JayaramanB Silver
Sep 28, 2014·Clinical Neuroradiology·T Boeckh-BehrensH Poppert
Feb 24, 2016·Lancet·Mayank GoyalUNKNOWN HERMES collaborators
Mar 5, 2016·Journal of Neurointerventional Surgery·Justus F KleineJohannes Kaesmacher
May 21, 2016·Stroke; a Journal of Cerebral Circulation·Tobias Boeckh-BehrensHolger Poppert
Jan 4, 2017·Journal of Neurointerventional Surgery·Gillian M GunningPatrick A Brouwer
Feb 17, 2017·Journal of the American Heart Association·Johannes KaesmacherJustus F Kleine
Jun 20, 2017·Stroke; a Journal of Cerebral Circulation·Peter B SpornsThomas Ulrich Niederstadt
Oct 24, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Christian MaegerleinJohannes Kaesmacher
Nov 14, 2017·Cerebrovascular Diseases·Peter B SpornsThomas Niederstadt
Jan 13, 2018·Stroke; a Journal of Cerebral Circulation·Heitor C AlvesUNKNOWN MR CLEAN trial investigators
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Maria BerndtTobias Boeckh-Behrens
Jun 27, 2019·Journal of Neurointerventional Surgery·John Charles BensonWaleed Brinjikji
Jun 28, 2019·Stroke; a Journal of Cerebral Circulation·Peter B SpornsUta Hanning