Small vessel disease/white matter disease of the brain and its association with osteoporosis

Journal of Clinical Medicine Research
Kannayiram AlagiakrishnanAmbikaipakan Senthilselvan

Abstract

Evidence now suggests the role of neural effect on bone mass control. The effect of small vessel disease of the brain on osteoporosis has not been studied. The aim of this study was to investigate the association of white matter disease (WMD) of the brain with osteoporosis in the elderly. In this retrospective cross-sectional study, 780 consecutive patient charts between 2010 and 2011 were reviewed in the Senior's Outpatient Clinic at the University of Alberta Hospital. Subjects with brain computerized tomography (CT) were included in the study. Subjects with incomplete information, intracranial hemorrhage, acute stroke, cerebral edema, and/or normal pressure hydrocephalus on the CT were excluded. WMD was quantified on CT using Wahlund's scoring protocol. Osteoporosis information was obtained from the chart, which has been diagnosed based on bone mineral density (BMD) information. Logistic regression analysis was done to determine the association of WMD severity with osteoporosis after controlling for confounding vascular risk factors. Of the 505 subjects who were included in the study, 188 (37%) had osteoporosis and 171 (91%) of these osteoporotic subjects were females. The mean age was 79.8 ± 7.04 years. The prevalence of WMD...Continue Reading

Citations

Feb 18, 2017·Nature Reviews. Neurology·Vincent C T MokLawrence K S Wong
Aug 2, 2018·International Journal of Molecular Sciences·Rita MorettiPaola Caruso

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Related Papers

Journal of Bone and Mineral Metabolism
Roberto Antonio MangiaficoCarmelo Erio Fiore
Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
Holly L FunkhouserRobert A Adler
© 2021 Meta ULC. All rights reserved