Small volume of hypertonic saline as the initial fluid replacement in experimental hypodynamic sepsis.

Critical Care : the Official Journal of the Critical Care Forum
Alejandra del Pilar Gallardo GarridoMaurício Rocha e Silva

Abstract

We conducted the present study to examine the effects of hypertonic saline solution (7.5%) on cardiovascular function and splanchnic perfusion in experimental sepsis. Anesthetized and mechanically ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over 30 minutes. After 30 minutes, they were randomized to receive lactated Ringer's solution 32 ml/kg (LR; n = 7) over 30 minutes or 7.5% hypertonic saline solution 4 ml/kg (HS; n = 8) over 5 minutes. They were observed without additional interventions for 120 minutes. Cardiac output (CO), mean arterial pressure (MAP), portal and renal blood flow (PBF and RBF, respectively), gastric partial pressure of CO2 (pCO2; gas tonometry), blood gases and lactate levels were assessed. E. coli infusion promoted significant reductions in CO, MAP, PBF and RBF (approximately 45%, 12%, 45% and 25%, respectively) accompanied by an increase in lactate levels and systemic and mesenteric oxygen extraction (sO2ER and mO2ER). Widening of venous-arterial (approximately 15 mmHg), portal-arterial (approximately 18 mmHg) and gastric mucosal-arterial (approximately 55 mmHg) pCO2 gradients were also observed. LR and HS infusion transiently improved systemic and regional blood flow...Continue Reading

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Citations

Nov 2, 2006·Current Opinion in Critical Care·Sean M Bagshaw, Rinaldo Bellomo
Sep 1, 2007·Current Opinion in Critical Care·Sean M Bagshaw, Rinaldo Bellomo
Dec 17, 2008·Critical Care Nursing Quarterly·Anil SinghPeter D Kaplan
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Mar 5, 2019·Anesthesia and Analgesia·Diego OrbegozoFuhong Su
May 17, 2019·Anesthesia and Analgesia·Diego OrbegozoFuhong Su
Nov 1, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Marcos Batista ReisLuiz Francisco Poli de Figueiredo
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Dec 17, 2009·The American Journal of Emergency Medicine·Go-Shine HuangChi-Yuan Li
Sep 21, 2010·The Journal of Surgical Research·Ruy J CruzMauricio Rocha-e-Silva

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Methods Mentioned

BETA
lavage

Software Mentioned

Stat
SPSS
Statistic Package for Social Sciences

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