Small Wonders-The Use of Nanoparticles for Delivering Antigen

Vaccines
Aya Taki, Peter Smooker

Abstract

Despite the discovery of many potential antigens for subunit vaccines, universal protection is often lacking due to the limitations of conventional delivery methods. Subunit vaccines primarily induce antibody-mediated humoral responses, whereas potent antigen-specific cellular responses are required for prevention against some pathogenic infections. Nanoparticles have been utilised in nanomedicine and are promising candidates for vaccine or drug delivery. Nanoparticle vehicles have been demonstrated to be efficiently taken up by dendritic cells and induce humoral and cellular responses. This review provides an overview of nanoparticle vaccine development; in particular, the preparation of nanoparticles using a templating technique is highlighted, which would alleviate some of the disadvantages of existing nanoparticles. We will also explore the cellular fate of nanoparticle vaccines. Nanoparticle-based antigen delivery systems have the potential to develop new generation vaccines against currently unpreventable infectious diseases.

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Citations

Apr 5, 2016·Vaccines·Vasso Apostolopoulos
Feb 9, 2017·International Journal of Molecular Sciences·Xiaoyuan MiaoQiu Zhang
Mar 30, 2017·Vaccine·Hayley K Charlton Hume, Linda H L Lua
Jul 18, 2017·Expert Review of Vaccines·Yahua LinQinjian Zhao
Feb 8, 2016·ACS Biomaterials Science & Engineering·Carrie E BrubakerJeffrey A Hubbell

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BETA
chemical treatment
PMA

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