Smaller Cerebellar Growth and Poorer Neurodevelopmental Outcomes in Very Preterm Infants Exposed to Neonatal Morphine

The Journal of Pediatrics
Jill G ZwickerEmily W Y Tam

Abstract

To examine the relationship between morphine exposure and growth of the cerebellum and cerebrum in very preterm neonates from early in life to term-equivalent age, as well as to examine morphine exposure and brain volumes in relation to neurodevelopmental outcomes at 18 months corrected age (CA). A prospective cohort of 136 very preterm neonates (24-32 weeks gestational age) was serially scanned with magnetic resonance imaging near birth and at term-equivalent age for volumetric measurements of the cerebellum and cerebrum. Motor outcomes were assessed with the Peabody Developmental Motor Scales, Second Edition and cognitive outcomes with the Bayley Scales of Infant and Toddler Development, Third Edition at 18 months CA. Generalized least squares models and linear regression models were used to assess relationships between morphine exposure, brain volumes, and neurodevelopmental outcomes. A 10-fold increase in morphine exposure was associated with a 5.5% decrease in cerebellar volume, after adjustment for multiple clinical confounders and total brain volume (P = .04). When infants exposed to glucocorticoids were excluded, the association of morphine was more pronounced, with an 8.1% decrease in cerebellar volume. Morphine exposu...Continue Reading

References

Nov 3, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·R MacGregorM Levene
Oct 2, 2007·American Journal of Perinatology·Rakesh RaoK J S Anand
Jun 18, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·R BellùR Zanini
Oct 22, 2010·The Journal of Pediatrics·Emily W Y TamA James Barkovich
Oct 21, 2011·Science Translational Medicine·Emily W Y TamSteven P Miller
Mar 1, 2012·Annals of Neurology·Susanne BrummelteSteven P Miller
Mar 17, 2012·The Journal of Pediatrics·Betty R VohrUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jul 31, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Horace MassaLaszlo Vutskits
Oct 6, 2012·Neonatology·Lasse DührsenUrsula Felderhoff-Mueser
Sep 3, 2013·The Cerebellum·Leonard F KoziolTadashi Yamazaki
Dec 7, 2013·The Annals of Pharmacotherapy·Erin M LammersJamie L Miller
Mar 29, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juliette SchuurmansFrank van Bel
Apr 15, 2015·Neonatology·Gerbrich E van den BoschMonique van Dijk
Apr 29, 2015·The Journal of Pediatrics·Rachel SteinhornTerrie Inder
May 20, 2015·The Journal of Pediatrics·Manon RangerRuth E Grunau
Jun 10, 2015·Pediatrics·Barynia BackeljauwAndreas W Loepke
Sep 16, 2015·The Annals of Pharmacotherapy·Christopher McPhersonTerrie E Inder

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Citations

Feb 21, 2016·The Journal of Pediatrics·Johannes N van den AnkerDick Tibboel
Jun 9, 2016·Acta Paediatrica·Kanwaljeet J S Anand
Jul 1, 2016·Seminars in Fetal & Neonatal Medicine·Matthew P G Allin
Sep 12, 2016·The Journal of Pediatrics·Liron Borenstein-LevinUNKNOWN Canadian Neonatal Network Investigators
Oct 30, 2016·The Journal of Pediatrics·Karina J KersbergenManon J N L Benders
Oct 28, 2016·Expert Review of Clinical Pharmacology·Manuel A BaarslagDick Tibboel
Dec 19, 2016·The Journal of Pediatrics·Dawn Gano, Donna M Ferriero
Apr 4, 2018·Radiology·Isabel Benavente-FernándezSimón P Lubián-López
Jan 11, 2018·Pediatric Research·Lillian G MatthewsTerrie E Inder
Jan 17, 2019·Clinical Pharmacology and Therapeutics·Frédérique RodieuxCaroline F Samer
Sep 30, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Chandler Rebecca Lee MongersonDusica Bajic
Jan 3, 2020·Pediatric Research·Christopher McPhersonTerrie E Inder
Sep 10, 2016·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Elizabeth AlloccoElisha M Wachman
Mar 4, 2017·Acta Paediatrica·Kanwaljeet J S AnandUNKNOWN EUROPAIN survey working group of the NeoOpioid Consortium
Apr 30, 2017·Human Reproduction·I V KoningR P M Steegers-Theunissen
May 17, 2018·Frontiers in Neurology·Hemmen SabirMarianne Thoresen
Feb 16, 2019·Journal of Neurosurgical Anesthesiology·Jerri ChenEmily W Y Tam
Apr 6, 2019·Frontiers in Physiology·Frank van BelFloris Groenendaal
May 22, 2019·Journal of Child Neurology·Emily W Y TamSteven P Miller
May 16, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx
Oct 21, 2020·Developmental Medicine and Child Neurology·Haixia GaoBin Wang
Dec 1, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Christopher McPhersonZachary Vesoulis
Jan 12, 2019·NeuroImage. Clinical·Marie Brossard-RacineCatherine Limperopoulos
Jan 22, 2021·The Cerebellum·Adaze Bijou Enogieru, Oghenakhogie Iroboudu Momodu
Mar 10, 2020·NeuroImage·Yao WuCatherine Limperopoulos
Apr 11, 2020·Early Human Development·M L TatarannoM J N L Benders
Feb 23, 2021·The European Journal of Neuroscience·Meggane MelchiorPierrick Poisbeau

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