Smaller prostate size predicts high grade prostate cancer at final pathology

The Journal of Urology
Mark R NewtonDaniel A Barocas

Abstract

Prostate size may influence the likelihood of detecting high grade prostate cancer at final pathology. We evaluated the association between prostate size and high grade (Gleason score 7 or greater) cancer. We analyzed data from 2,880 patients who underwent surgical treatment of prostate cancer between January 2000 and June 2008. Prostate size measured at prostatectomy was compared across a strata of clinical variables (age, body mass index, prostate specific antigen, biopsy Gleason score, clinical stage and year of surgery) and pathological outcomes (final Gleason score, extraprostatic extension, positive surgical margin, seminal vesicle invasion and lymph node involvement). Multivariate logistic regression was used to assess prostate size as a predictor of high grade cancer. Older age, higher prostate specific antigen and later year of surgery were associated with larger gland size. Small prostate size was associated with high grade prostate cancer as well as extraprostatic extension and positive surgical margins on univariate and adjusted analysis. The probability of high grade disease decreased approximately 15% across the lowest vs highest prostate sizes. On multivariate analysis adjusted for age, race, prostate specific an...Continue Reading

References

Nov 1, 1992·Journal of Computer Assisted Tomography·A RahmouniE Zerhouni
Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
Oct 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J ZelefskyS A Leibel
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanS A Leibel
Jan 4, 2001·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·B J SpeckM J Belyea
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J PetrelliBruce Minsky
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen J FreedlandChristopher J Kane
Jan 13, 2006·The Journal of Urology·Girish S KulkarniNeil E Fleshner
Dec 13, 2006·The Journal of Urology·E W SteyerbergF H Schröder
Sep 13, 2007·Journal of the National Cancer Institute·M Scott LuciaIan M Thompson
Nov 13, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alberto BrigantiPierre I Karakiewicz
Dec 20, 2007·American Journal of Clinical Pathology·Jonathan I EpsteinUNKNOWN Association of Directors of Anatomic and Surgical Pathology
Jan 22, 2008·The Journal of Urology·Fei DongEric A Klein
Oct 1, 2008·Cancer·Shahrokh F ShariatMichael W Kattan
Jun 23, 2009·Cancer·Chris H BangmaEwout W Steyerberg

❮ Previous
Next ❯

Citations

Dec 23, 2011·Actas urologicas españolas·C González-EnguitaR Vela-Navarrete
Jul 16, 2013·International Journal of Radiation Oncology, Biology, Physics·Hien LePeter Hoskin
Apr 17, 2012·International Journal of Radiation Oncology, Biology, Physics·Al V TairaKent E Wallner
Jan 25, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Tsutomu Nishiyama
Dec 20, 2011·The Journal of Urology·Tin C NgoJoseph C Presti
Oct 22, 2011·The Journal of Urology·Judson D DaviesDaniel A Barocas
Sep 29, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J-F PekoA Ngolet
Apr 19, 2011·The Journal of Urology·Jen-Jane LiuJoseph C Presti
Mar 5, 2013·BJU International·Kwang Hyun KimSung Joon Hong
Aug 7, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Nicolas KoutlidisLuc Cormier
Dec 21, 2016·World Journal of Urology·Cedric LebacleLaurent Salomon
Dec 17, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hasan YilmazOzdal Dillioglugil
Jan 11, 2018·Endocrine-related Cancer·Clovis Boibessot, Paul Toren
Jan 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Guillermo LorenzoHector Gomez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.