Abstract
Prostate size may influence the likelihood of detecting high grade prostate cancer at final pathology. We evaluated the association between prostate size and high grade (Gleason score 7 or greater) cancer. We analyzed data from 2,880 patients who underwent surgical treatment of prostate cancer between January 2000 and June 2008. Prostate size measured at prostatectomy was compared across a strata of clinical variables (age, body mass index, prostate specific antigen, biopsy Gleason score, clinical stage and year of surgery) and pathological outcomes (final Gleason score, extraprostatic extension, positive surgical margin, seminal vesicle invasion and lymph node involvement). Multivariate logistic regression was used to assess prostate size as a predictor of high grade cancer. Older age, higher prostate specific antigen and later year of surgery were associated with larger gland size. Small prostate size was associated with high grade prostate cancer as well as extraprostatic extension and positive surgical margins on univariate and adjusted analysis. The probability of high grade disease decreased approximately 15% across the lowest vs highest prostate sizes. On multivariate analysis adjusted for age, race, prostate specific an...Continue Reading
References
Nov 1, 1992·Journal of Computer Assisted Tomography·A RahmouniE Zerhouni
Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Sep 1, 1996·The Journal of Urology·Y GotoP T Scardino
Jan 15, 1997·Cancer·T M PisanskyD G Bostwick
May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
Oct 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J ZelefskyS A Leibel
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanS A Leibel
Jan 4, 2001·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·B J SpeckM J Belyea
Sep 11, 2001·Urology·M W KattanP T Scardino
Oct 10, 2001·The Urologic Clinics of North America·M HanP C Walsh
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Dec 14, 2004·The Journal of Urology·Steven LehrerRichard G Stock
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J PetrelliBruce Minsky
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen J FreedlandChristopher J Kane
Jan 13, 2006·The Journal of Urology·Girish S KulkarniNeil E Fleshner
Dec 13, 2006·The Journal of Urology·E W SteyerbergF H Schröder
Dec 16, 2006·Urology·Aimee L QuanEric A Klein
Feb 27, 2007·Urology·Fernando J BiancoMichael W Kattan
May 15, 2007·Cancer·Girish S KulkarniNeil E Fleshner
May 15, 2007·The Journal of Urology·Wassim KassoufR Joseph Babaian
Jun 19, 2007·Urology·Danil V MakarovAlan W Partin
Sep 13, 2007·Journal of the National Cancer Institute·M Scott LuciaIan M Thompson
Nov 13, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alberto BrigantiPierre I Karakiewicz
Dec 20, 2007·American Journal of Clinical Pathology·Jonathan I EpsteinUNKNOWN Association of Directors of Anatomic and Surgical Pathology
Jan 22, 2008·The Journal of Urology·Fei DongEric A Klein
Oct 1, 2008·Cancer·Shahrokh F ShariatMichael W Kattan
Jun 23, 2009·International Journal of Radiation Oncology, Biology, Physics·Louis PottersMichael W Kattan
Jun 23, 2009·Cancer·Mack RoachAlan Pollack
Jun 23, 2009·Cancer·Carvell T NguyenMichael W Kattan
Jun 23, 2009·Cancer·Chris H BangmaEwout W Steyerberg
Citations
Jun 25, 2014·Urology·Michael A KozminskiTodd M Morgan
Jun 16, 2014·Urology·Eugene J PietzakThomas J Guzzo
Dec 23, 2011·Actas urologicas españolas·C González-EnguitaR Vela-Navarrete
Dec 20, 2011·Actas urologicas españolas·R Vela-Navarrete
Jul 16, 2013·International Journal of Radiation Oncology, Biology, Physics·Hien LePeter Hoskin
Aug 29, 2012·Urology·Ronald H Shapiro, Peter A S Johnstone
Apr 17, 2012·International Journal of Radiation Oncology, Biology, Physics·Al V TairaKent E Wallner
Jan 25, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Tsutomu Nishiyama
Dec 20, 2011·The Journal of Urology·Tin C NgoJoseph C Presti
Nov 15, 2011·European Urology·Selahattin Calişkan
Oct 25, 2011·The Journal of Urology·Selahattin Calışkan
Oct 22, 2011·The Journal of Urology·Judson D DaviesDaniel A Barocas
Sep 29, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J-F PekoA Ngolet
Apr 19, 2011·The Journal of Urology·Jen-Jane LiuJoseph C Presti
Aug 8, 2014·BJU International·Patrick H TuliaoKoon Ho Rha
Mar 5, 2013·BJU International·Kwang Hyun KimSung Joon Hong
Aug 7, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Nicolas KoutlidisLuc Cormier
Nov 19, 2015·Surgical Endoscopy·Yosuke HirasawaKunihiko Yoshioka
Jul 1, 2014·Urology·Sung Kyu HongJames A Eastham
Dec 21, 2016·World Journal of Urology·Cedric LebacleLaurent Salomon
Dec 17, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hasan YilmazOzdal Dillioglugil
Jan 11, 2018·Endocrine-related Cancer·Clovis Boibessot, Paul Toren
Nov 1, 2013·Korean journal of urology·Tae Il NohJae Young Park
May 13, 2018·Abdominal Radiology·Julie Y AnBaris Turkbey
Nov 8, 2017·Oncotarget·Tian YangQiang Ding
Oct 28, 2019·EJNMMI Physics·J Olde HeuvelC H Slump
Jan 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Guillermo LorenzoHector Gomez
Jan 18, 2018·Cancer Medicine·Takayoshi DemuraHiroko Gotoda
Apr 20, 2021·Therapeutic Advances in Urology·Jake SellersWerner T W de Riese
Aug 11, 2021·The Prostate·Kiran R NandalurJason Hafron