Smart Cancer Cell Targeting Imaging and Drug Delivery System by Systematically Engineering Periodic Mesoporous Organosilica Nanoparticles

ACS Applied Materials & Interfaces
Nan LuGuangming Lu

Abstract

The integration of diagnosis and therapy into one nanoplatform, known as theranostics, has attracted increasing attention in the biomedical areas. Herein, we first present a cancer cell targeting imaging and drug delivery system based on engineered thioether-bridged periodic mesoporous organosilica nanoparticles (PMOs). The PMOs are stably and selectively conjugated with near-infrared fluorescence (NIRF) dye Cyanine 5.5 (Cy5.5) and anti-Her2 affibody on the outer surfaces to endow them with excellent NIRF imaging and cancer targeting properties. Also, taking the advantage of the thioether-group-incorporated mesopores, the release of chemotherapy drug doxorubicin (DOX) loaded in the PMOs is responsive to the tumor-related molecule glutathione (GSH). The drug release percentage reaches 84.8% in 10 mM of GSH solution within 24 h, which is more than 2-fold higher than that without GSH. In addition, the drug release also exhibits pH-responsive, which reaches 53.6% at pH 5 and 31.7% at pH 7.4 within 24 h. Confocal laser scanning microscopy and flow cytometry analysis demonstrate that the PMOs-based theranostic platforms can efficiently target to and enter Her2 positive tumor cells. Thus, the smart imaging and drug delivery nanoplatfo...Continue Reading

References

Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gernot HabichtMarcus Fändrich
Jun 3, 2008·Advanced Drug Delivery Reviews·Igor I SlowingVictor S-Y Lin
Aug 10, 2010·Advanced Drug Delivery Reviews·Jin XieXiaoyuan Chen
Oct 1, 2010·Advanced Materials·Sonja BauhuberAchim Göpferich
May 3, 2011·Accounts of Chemical Research·Younan XiaPaige K Brown
Aug 19, 2011·Accounts of Chemical Research·Ji Eun LeeTaeghwan Hyeon
Apr 24, 2012·Chemical Communications : Chem Comm·Mei-Yi LiaoChih-Chia Huang
Apr 13, 2013·Chemical Reviews·Min Hee LeeJong Seung Kim
Oct 30, 2014·ACS Applied Materials & Interfaces·Shreya GoelWeibo Cai
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jul 8, 2015·ACS Nano·Mengxiao Yu, Jie Zheng
Jul 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue-Hua MaAi-Guo Wu
Jul 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuxia TangGuangming Lu

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Citations

Mar 6, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Hang HuoKaifeng Lin
Oct 5, 2018·Advanced Materials·Zhaogang TengDongyuan Zhao
Aug 31, 2017·Nanoscale·Nikola Ž Knežević, Goran N Kaluđerović
Apr 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meng DangLianhui Wang
Mar 11, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafaela S GuimarãesIlídio J Correia
May 1, 2021·Pharmaceutics·Alex N FrickensteinLacey R McNally
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ngoc Xuan Dat MaiTan Le Hoang Doan
May 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Arpan BiswasPralay Maiti
Aug 29, 2017·ACS Applied Materials & Interfaces·Roza BouchalPeter Hesemann
Oct 14, 2019·ACS Biomaterials Science & Engineering·Priti SinghSunil Kumar Singh
Jan 8, 2018·ACS Biomaterials Science & Engineering·Kummara Madhusudana RaoSung Soo Han

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